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(17beta)-estra-1,3,5(10)-triene-1,3,17-triol, commonly known as estriol, is a naturally occurring estrogen hormone that is primarily produced by the placenta during pregnancy. As a steroid hormone, it plays a vital role in the regulation and maintenance of the female reproductive system. Estriol is characterized by its unique chemical structure, which includes three hydroxyl groups at positions 1, 3, and 17, and a double bond pattern in its steroid nucleus. This hormone is known for its significant impact on various physiological processes, including fetal development and maternal health.

4147-05-1

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4147-05-1 Usage

Uses

Used in Menopausal Hormone Replacement Therapy:
Estriol is utilized as a hormone replacement therapy (HRT) agent for menopausal women, specifically to alleviate symptoms associated with menopause, such as hot flashes and vaginal dryness. Its use in HRT is attributed to its milder estrogenic effects compared to other forms of estrogen, which may result in fewer side effects and a lower risk of endometrial cancer.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, estriol is used as an ingredient in various medications designed to address hormonal imbalances and related conditions. Its role in these formulations is to provide estrogenic support, which can help in managing symptoms and promoting overall well-being in individuals experiencing hormonal changes.
Used in Research and Development:
Estriol is also used in research settings to study the effects of estrogen on various physiological processes. Its unique properties make it a valuable tool for investigating the role of estrogen in reproductive health, fetal development, and other areas of medical interest.
Used in the Treatment of Osteoporosis:
Estriol has been studied for its potential benefits in treating osteoporosis, a condition characterized by a decrease in bone density and an increased risk of fractures. Its use in this context is based on the understanding that estrogen plays a role in maintaining bone health, and estriol may help to counteract the bone loss associated with menopause and other conditions.
Used in the Management of Multiple Sclerosis:
Research has also explored the potential of estriol in managing multiple sclerosis, a chronic autoimmune disease that affects the central nervous system. While the exact mechanisms are not fully understood, estriol's anti-inflammatory and neuroprotective properties suggest that it may have therapeutic benefits for individuals with this condition.

Check Digit Verification of cas no

The CAS Registry Mumber 4147-05-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,4 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4147-05:
(6*4)+(5*1)+(4*4)+(3*7)+(2*0)+(1*5)=71
71 % 10 = 1
So 4147-05-1 is a valid CAS Registry Number.

4147-05-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-1,3,17-triol

1.2 Other means of identification

Product number -
Other names 1-Hydroxyestradiol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4147-05-1 SDS

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