414858-02-9 Usage
Uses
Used in Pharmaceutical Industry:
1,4,8,11-Tetraazacyclotetradecane, 1,8-bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]is used as an impurity in the production of Plerixafor (P580500), a hematopoietic stem cell (HSC) mobilizer. Plerixafor is a CXCR4 chemokine receptor inhibitor that blocks the binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α), and is approved for use in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).
Check Digit Verification of cas no
The CAS Registry Mumber 414858-02-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,1,4,8,5 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 414858-02:
(8*4)+(7*1)+(6*4)+(5*8)+(4*5)+(3*8)+(2*0)+(1*2)=149
149 % 10 = 9
So 414858-02-9 is a valid CAS Registry Number.
414858-02-9Relevant academic research and scientific papers
Dong,Lindoy
, p. 291 - 297 (2001)
The synthesis of the four single-ring cyclam derivatives together with the related tri-linked ring derivatives and tetrabenzylated derivative was reported. In the synthesis, differential Boc-protected cyclam derivatives were used as key intermediates. Benzylated and tri-linked cyclam products were found to rely heavily on high-resolution mass spectrometry (HRMS) and all compounds yielded satisfactory HRMS data.
