41487-00-7

Basic information

• Product Name: Z-ILE-VAL-OH
• Synonyms: Z-ILE-VAL-OH;Z-L-ISOLEUCYL-L-VALINE;N-[N-[(benzyloxy)carbonyl]-L-isoleucyl]-L-valine;Z-L-Ile-L-Val-OH;2-[[2-(benzyloxycarbonylamino)-3-methyl-pentanoyl]amino]-3-methyl-butyric acid;3-methyl-2-[[3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]butanoic acid
• CAS NO: 41487-00-7
• Molecular Formula: C₁₉H₂₈N₂O₅
• Molecular Weight: 364.44
• EINECS: 255-395-4
• Mol File: 41487-00-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 590.1°Cat760mmHg
• Flash Point: 310.7°C
• Appearance: /
• Density: 1.145g/cm³
• Vapor Pressure: 8.99E-15mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-ILE-VAL-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-ILE-VAL-OH(41487-00-7)
• EPA Substance Registry System: Z-ILE-VAL-OH(41487-00-7)

Safety Data

• Hazardous Substances Data: 41487-00-7(Hazardous Substances Data)

Usage

Description

Z-ILE-VAL-OH, also known as N-(tert-butoxycarbonyl)-L-isoleucyl-L-valine, is a peptide compound derived from the amino acids isoleucine and valine. It is often utilized in research and laboratory settings to study protein synthesis, structure, and function. As a short chain of amino acids, Z-ILE-VAL-OH aids in investigating the interactions and behavior of proteins and enzymes within biological systems. Additionally, it may have potential applications in drug development and pharmaceuticals, given its involvement in the synthesis and modification of peptides for therapeutic purposes.

Uses

Used in Research and Laboratory Settings:
Z-ILE-VAL-OH is used as a research compound for studying protein synthesis, structure, and function. It helps scientists understand the interactions and behavior of proteins and enzymes within biological systems.
Used in Drug Development and Pharmaceuticals:
Z-ILE-VAL-OH is used as a peptide in the synthesis and modification of therapeutic peptides. Its potential applications in drug development and pharmaceuticals make it a valuable tool for creating new treatments and medications.

InChI:InChI=1/C19H28N2O5/c1-5-13(4)16(17(22)20-15(12(2)3)18(23)24)21-19(25)26-11-14-9-7-6-8-10-14/h6-10,12-13,15-16H,5,11H2,1-4H3,(H,20,22)(H,21,25)(H,23,24)

Upstream product

• 88962-38-3 N-Benzyloxycarbonyl-L-isoleucyl-L-valin-2-bromethylester 
• 88962-27-0 Valin-2-bromethylester-hydrochlorid 
• 3160-59-6 N-Cbz-L-Isoleucine 
• 72-18-4 L-valine 
• 53665-97-7 Z-Ile-ONB 
• 3391-99-9 N-Z-L-isoleucine N-hydroxysuccinimide ester 

Downstream Products

• 73809-01-5 Boc-GlyIleValGlu(OBut)Gln(Mbh)-OH 
• 41017-96-3 L-isoleucyl-L-valine 
• 94359-91-8 Z-Ile-Val-NHCH₂Ph 

Relevant articles and documents

Glycopeptide Synthesis: Selective C-terminal Deblocking and Peptide Chain Elongation of Glucosylserine Derivatives

Benzyloxycarbonyl-(Z-)serine 2-bromoethyl ester (3b) reacts with 2,3,4,6-tetra-O-benzoyl-α-D-glucopyranosyl bromide (14) to give the glucosylserine ester 15.After conversion into the corresponding 2-iodoethyl ester 23 the carboxylic group is deblocked selectively by reductive elimination using zinc.In this procedure the Z and the carbohydrate protective functions as well as the sensitive O-glycoside bond remain unaffected.The glycosylserine 24 is condensed with amino acid 2-bromoethyl esters 2 to form protected glycodipeptide 2-bromoethyl esters 18 which are extended to give glycotripeptide esters 25 after selective carboxyl deblocking.Whereas protected serine dipeptides 5 are glycosylated with 14 to form the conjugates 18, the glycosylation of the serine tripeptides 10 was not successful.

Synthesis of N-terminal peptide fragments of the insulin A-chain

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