414875-72-2Relevant academic research and scientific papers
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators
Colabufo, Nicola Antonio,Berardi, Francesco,Cantore, Mariangela,Perrone, Maria Grazia,Contino, Marialessandra,Inglese, Carmela,Niso, Mauro,Perrone, Roberto,Azzariti, Amalia,Simone, Grazia Maria,Paradiso, Angelo
, p. 3732 - 3743 (2008/12/21)
Starting from lead compound 1 (EC50 = 1.64 μM), its non-basic nucleus has been conformationally restricted by 4-biphenyl and 2-naphthyl moieties. In each series we investigated if the presence of H-bond donor or acceptor substituents, the basic
