414894-70-5

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 109-77-3 malononitrile 
• 108-46-3 recorcinol 

Relevant academic research and scientific papers

Tungstic acid functionalized mesoporous SBA-15: A novel heterogeneous catalyst for facile one-pot synthesis of 2-amino-4H-chromenes in aqueous medium

A new highly ordered mesoporous tungstic acid functionalized SBA-15, TAFMC-1 has been synthesized via post-synthesis modification of mesoporous SBA-15 with (3-chloropropyl) triethoxysilane followed by substitution reaction of chlorine atom of the 3-chloropropyl group by tungstic acid group under refluxing conditions in n-hexane. The tungstic acid functionalized mesoporous silica material has been characterized by using small angle powder X-ray diffraction, N2 sorption, HR-TEM, FE-SEM, FT-IR and solid state MAS NMR studies. TAFMC-1 catalyzes the facile one-pot catalytic three-component condensation reaction of resorcinol, aromatic aldehyde and malononitrile for the synthesis of a diverse range of 2-amino-4H-chromenes in aqueous medium. This heterogeneous catalyst can be recycled very efficiently for six consecutive reaction cycles without significant loss of catalytic activity.

Biocompatible Ionic Liquid Promote One-Pot Synthesis of 2-Amino-4H-Chromenes Under Ambient Conditions

Abstract: The synthesis of 2-amino-4H-chromenes through one-pot multicomponent reactions has received great attention due to the high atom efficiency and the broad bioactivities of the products. Here, the catalytic performances of a series of functional ionic liquids towards this type of reaction were investigated and the results showed that the ionic liquid, choline acetate ([Choline][Ac]), could efficiently promote this reactions under room temperature without the necessary of organic solvents. The reaction is easy to be conducted and the following work-up procedures are very simple. The pure products can be obtained through extraction and washing procedures, no column separation procedures are needed. Intriguingly, this reaction system can be easily scaled up to multi-gram, suggesting its perspective in industrial applications. In addition, the ionic liquid [Choline][Ac] can be easily prepared from cheap and biocompatible materials, and it can be feasibly recycled and reutilized for at least five cycles. Graphic Abstract: Various aldehydes, malononitrile and activated phenols could be converted to thecorresponding 2-amino-4H-chromenes with good to excellent isolated yields underthe catalysis of choline acetate at room temperature. [Figure not available: see fulltext.]

Choline hydroxide promoted 2-amino-3-nitrile-7-hydroxyl-4H-chromene derivative one-pot synthesis method

The invention discloses a choline hydroxide promoted 2-amino-3-nitrile-7-hydroxyl-4H-chromene derivative one-pot synthesis method. Reaction substrates including a phenol compound, an aromatic aldehydecompound and malononitrile and a catalyst namely cholin

Method for preparing 2-amino-4H-chromene derivative by one-pot method promoted by hydrogen bond functionalized ionic liquid

The invention discloses a method for preparing a 2-amino-4H-chromene derivative by one-pot method promoted by a hydrogen bond functionalized ionic liquid. According to the method, a phenol compound, an aromatic aldehyde compound and malononitrile are used

Enhancement of catalytic activity in the synthesis of 2-amino-4H-chromene derivatives using both copper- and cobalt-incorporated magnetic ferrite nanoparticles

Cu0.5Co0.5Fe2O4 magnetic nanoparticles were prepared, characterized and employed as bench-top, highly active and magnetically separable nanocatalysts for the synthesis of 2-amino-4H-chromene derivatives. A wide

An efficient, one-pot synthesis of 2-amino-4H-chromenes catalyzed by (α-Fe2O3)-MCM-41-supported dual acidic ionic liquid as a novel and recyclable magnetic nanocatalyst

A novel (α-Fe2O3)-MCM-41-supported dual acidic ionic liquid (DAIL) catalytic system was prepared. This catalyst was characterized by XRD, TEM, SEM, IR spectra and N2 adsorption-desorption measurements, TGA and acid-base titration. 1-Methyl-3-(4-sulfobutyl) imidazolium hydrogen sulfate as the DAIL inside the mesochannels of α-Fe2O3-MCM-41 led to preparation of a new material which was an efficient magnetic heterogeneous nanocatalyst for one-pot three-component synthesis of some new and known 2-amino-4H-chromenes in water medium conditions. This catalyst was more efficient than other reported catalysts for the synthesis of 2-amino-3-cyano-7-hydroxy-4H-chromenes. High product yields, short reaction times, use of non-corrosives, a robust and reusable magnetic nanocatalyst and water as a green solvent are the most important features of the present work. Graphical Abstract: [Figure not available: see fulltext.]