414910-07-9

Upstream product

• 629953-69-1 2-(4-fluoro-2-methylphenyl)-4,4-dimethoxypiperidine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 511256-36-3 (S)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine 
• 414909-99-2 2-(4-fluoro-2-methyl-phenyl)-piperidine-4-one 
• 414910-08-0 (1S)-1-[3,5-bis(trifluoromethyl)phenyl]-N-methylethanamine hydrochloride 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 1204820-81-4 ethyl (1R,5R)-3-[(2R,4R)-1-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-piperidinyl]-3-azabicyclo[3.1.0]hexane-1-carboxylate 
• 1204820-82-5 ethyl (1R,5R)-3-[(2R,4S)-1-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-piperidinyl]-3-azabicyclo[3.1.0]hexane-1-carboxylate 
• 1204820-79-0 ethyl 3-[(2R,4R)-1-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-piperidinyl]-3-azabicyclo[3.1.0]hexane-1-carboxylate 
• 1204820-83-6 ethyl (1S,5S)-3-[(2R,4S)-1-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-piperidinyl]-3-azabicyclo[3.1.0]hexane-1-carboxylate 
• 629922-53-8 (2R,4S)-1-[N-{1-(S)-(3,5-bistrifluoromethylphenyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine 

Relevant academic research and scientific papers

THIOMORPHOLINE COMPOUND AND PROCESS FOR PREPARING THE SAME

The present invention discloses a thiomorpholine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring; Ring B represents an optionally substituted benzene ring; R1 represents hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom; R2 represents hydrogen atom or an optionally substituted alkyl group; and R3a and R3b may be the same or different from each other, and each represent hydrogen atom or an optionally substituted alkyl group, or combined to each other at the both ends thereof to form an alkylene group, and n is an integer of 1 or 2, or a pharmaceutically acceptable salt thereof.

Chemical compounds

Formula (1) wherein R represents a halogen atom or a C1-4 alkyl group; R1 represents a C1-4 alkyl group; R2 represents hydrogen or a C1-4 alkyl group; R3 represents hydrogen, or a C1-4 alkyl group; R4 represents a trifluorometyl group; R5 represents hydrogen, a C1-4 alkyl group or C(0)R6; R6? represents C1-4 alkyl, C3-7 cycloalkyl, NH(C1-4 alkyl) or N(C1-4alkyl)2; m is zero or an integer from 1 to 3; n is an integer from 1 to 3 and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation and their use in the treatment of conditions mediated bytachykinins.

NOVEL PIPERIDINE COMPOUND

The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted alkyl group, an optionally substituted hydroxyl group, etc., or a group of the formula: (a) wherein R11 and R12 are the same or different, and each represents hydrogen atom, a substituted carbonyl group, a substituted sulfonyl group, an optionally substituted alkyl group, etc., R2 represents hydrogen atom, etc., Z represents oxygen atom or a group represented by -N(R3)-, R3 represents hydrogen atom or an alkyl group, etc., R4 represents hydrogen atom or an alkyl group, etc.,or a pharmaceutically acceptable salt thereof.