41513-01-3

Upstream product

• 79-41-4 poly(methacrylic acid) 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 920-46-7 Methacryloyl chloride 

Downstream Products

• 888072-77-3 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-bromo-3-trifluoromethyl-phenyl)-amide 
• 946160-18-5 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-bromo-3-trifluoromethyl-phenyl)-amide 

Relevant academic research and scientific papers

Design, synthesis, and in vivo SAR of a novel series of pyrazolines as potent selective androgen receptor modulators

A novel series of pyrazolines 2 have been designed, synthesized, and evaluated by in vivo screening as tissue-selective androgen receptor modulators (SARMs). Structure-activity relationships (SAR) were investigated at the R 1 to R6 positions as well as the core pyrazoline ring and the anilide linker. Overall, strong electron-withdrawing groups at the R 1 and R2 positions and a small group at the R5 and R6 position are optimal for AR agonist activity. The (S)-isomer of 7c exhibits more potent AR agonist activity than the corresponding (R)-isomer. (S)-7c exhibited an overall partial androgenic effect but full anabolic effect via oral administration in castrated rats. It demonstrated a noticeable antiandrogenic effect on prostate in intact rats with endogenous testosterone. Thus, (S)-7c is a tissue-selective nonsteroidal androgen receptor modulator with agonist activity on muscle and mixed agonist and antagonist activity on prostate.

Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators

A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.