41520-38-1Relevant articles and documents
Novel D-A-D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease
Li, Yuying,Wang, Kan,Zhou, Kaixiang,Guo, Wentao,Dai, Bin,Liang, Yi,Dai, Jiapei,Cui, Mengchao
supporting information, p. 8717 - 8720 (2018/08/09)
Novel D-π-A-π-D probes were investigated for the detection of Aβ plaques and NFTs. The probes displayed remarkable optical properties, and DADNIR-2 possessed high affinity towards Tau and Aβ aggregates (Kd = 0.41 nM and 1.04 nM, respectively) with certain selectivity. DADNIR-2 could penetrate the BBB and label Aβ plaques in vivo.