4156-61-0

Upstream product

• 64-17-5 ethanol 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 

Downstream Products

• 137206-52-1 (3,4,5-Trimethoxy-phenyl)-acetic acid N'-[imino-(3,4,5-trimethoxy-phenyl)-methyl]-hydrazide 
• 1041643-80-4 C₁₃H₁₆N₂O₅ 
• 4156-59-6 3,4,5-trimethoxy benzenecarboximidamide hydrochloride 
• 137206-47-4 3-(3,4,5-trimethoxyphenylmethyl)-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazole 
• 107190-58-9 C₁₇H₂₀Cl₂N₆O₃ 
• 107190-57-8 C₂₀H₂₅N₃O₆ 
• 107190-56-7 C₁₉H₂₃N₃O₅ 
• 107190-54-5 C₁₇H₁₈ClN₃O₃ 
• 107190-55-6 C₁₇H₁₈ClN₃O₃ 
• 107190-53-4 N¹-(2,6-dichlorobenzyliden)-3,4,5-trimethoxybenzamidrazone 
• 107190-62-5 3,4,5-trimethoxybenzamidrazone 

Relevant academic research and scientific papers

Facile synthesis of 3,5-diaryl-1,2,4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates

Two methods for the synthesis of 3,5-diaryl-1,2,4-triazoles, both domino reactions, are reported. The first procedure, the Cu(OTf)2-catalyzed reaction between two amidines using NaHCO3 as a base, 1,10-phenanthroline as an additive and K3[Fe(CN)6]/ atmospheric oxygen as the oxidant, delivers 3,5-diaryl-1,2,4-triazoles with yields up to 68%. The second procedure for the synthesis of 3,5-diaryl-1,2,4- triazoles with yields up to 64% rests on the Cu(OTf)2-catalyzed reaction between two imidates and ammonium carbonate. This method features the formation of three bonds in a single synthetic step.

Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma

We have previously reported substituted 2-aryl-thiazolidine-4-carboxylic acid amides as potent and selective antiproliferative agents for melanoma. To understand the importance of the thiazolidine ring and to reduce potential complications associated with the two chiral centers, we designed and synthesized sets of new analogs by modifying this ring. These new analogs were tested in two melanoma cell lines and fibroblast cells (negative controls). Compared with the older analogs containing the thiazolidine ring, these new analogs have lower potency in general, but some of these analogs still have very good selectivity. These structure-activity studies indicated that the thiazolidine ring is very critical for the activity for these series of compounds.