415693-32-2Relevant academic research and scientific papers
The first supported N-pyridinyl proline-derived chiral catalyst for the kinetic resolution of racemic alcohols
Pelotier, Béatrice,Priem, Ghislaine,Campbell, Ian B.,Macdonald, Simon J. F.,Anson, Mike S.
, p. 679 - 683 (2003)
A family of polymer-supported chiral acylation catalysts derived from N-4′-pyridinyl-α-methyl-proline has been synthesised and screened in the kinetic resolution of racemic alcohol 1. The best supported catalyst 4 behaves in most cases as its solution phase analog 13 in the enantioselective acylation of a range of alcohols and can be recycled without loss of activity or selectivity.
Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst: Access to enantiopure cyclic cis-amino alcohols
Kawabata,Yamamoto,Momose,Yoshida,Nagaoka,Fuji
, p. 2700 - 2701 (2007/10/03)
Acylative kinetic resolution of racemic cyclic cis-amino alcohol derivatives with a chiral nucleophilic catalyst proceeds enantioselectively (s = 10-21) at ambient temperature to give enantiopure recovered materials, and the % conversion of the acylation can be readily controlled by the amount of acid anhydride.
