415696-70-7Relevant academic research and scientific papers
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer
Yu, Chao-Wu,Hung, Pei-Yun,Yang, Hui-Ting,Ho, Yi-Hsun,Lai, Hsing-Yi,Cheng, Yi-Sheng,Chern, Ji-Wang
, p. 857 - 874 (2019/01/08)
We designed and synthesized quinazolin-2,4-dione-based hydroxamic acids to serve as selective competitive inhibitors of histone deacetylase-6 (HDAC6). The most potent and selective compound, 3d (IC50, 4 nM, HDAC6; IC50 > 10 μM, HDAC1
Syntheses of quinazoline-2,4-dione alkaloids and analogues from Mexican Zanthoxylum species
Rivero,Espinoza,Somanathan
, p. 609 - 616 (2007/10/03)
Quinazolinone and quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. In this paper we report the synthesis of ten quinazolinediones. The previous isolation of two of these compounds, namely 1-methyl-3-(2′-phenylethyl)-1H,3H-quinazoline-2,4-dione and 1-methyl-3-[2′-(4′-methoxyphenyl)ethyl]-1H,3H-quinazoline-2,4- dione, from the seed husks of Mexican Zanthoxylum species has been reported.
