2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER is a complex organic compound with potential applications in various fields due to its unique chemical structure and properties.
415697-08-4
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Basic information
- Product Name: 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
- Synonyms: SN-6;2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
- CAS NO:415697-08-4
- Molecular Formula: C20H22N2O5S
- Molecular Weight: 402.46
- EINECS: N/A
- Product Categories: Ion transporter and other ion channel
- Mol File: 415697-08-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 581.2°Cat760mmHg
- Flash Point: 305.3°C
- Appearance: /
- Density: 1.285g/cm3
- Vapor Pressure: 0mmHg at 25°C
- Refractive Index: 1.605
- Storage Temp.: Desiccate at +4°C
- Solubility: N/A
- PKA: 6.63±0.60(Predicted)
- CAS DataBase Reference: 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
- NIST Chemistry Reference: 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER(415697-08-4)
- EPA Substance Registry System: 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER(415697-08-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 415697-08-4(Hazardous Substances Data)
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415697-08-4 Usage
Uses
Used in Pharmaceutical Industry:2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER is used as an inhibitor of the Na+/Ca+ exchanger (NCX) for its potential to ameliorate cardiac ischemia-reperfusion injury and promote high-frequency fatigue of skeletal muscle.
Used in Inflammation and Pain Management:
In the field of inflammation and pain management, 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER is used as an inhibitor to reduce the expression of cyclooxygenase (COX-2), which is induced by bafilomycin A1. This inhibition can help in managing inflammation and pain by reducing the production of prostaglandins, which are involved in the inflammatory response and pain sensation.
Biological Activity
Selective Na + /Ca 2+ -exchange (NCX) inhibitor; displays some selectivity for NCX1. IC 50 values are 2.9, 16 and 8.6 μ M for inhibition of intracellular Na+-dependent 45 Ca 2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC 50 = 18 μ M) but minimal activity against NCKX2 and various receptors and ion channels (IC 50 > 30 μ M). Preferentially blocks Ca 2+ influx mode and is more selective for NCX isoforms than KB-R7943 (2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate ). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC 50 = 0.63 μ M).Check Digit Verification of cas no
The CAS Registry Mumber 415697-08-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,1,5,6,9 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.Calculate Digit Verification of CAS Registry Number 415697-08:
(8*4)+(7*1)+(6*5)+(5*6)+(4*9)+(3*7)+(2*0)+(1*8)=164
164 % 10 = 4
So 415697-08-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3
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2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
