41571-57-7Relevant academic research and scientific papers
Novel synthetic route to octasubstituted naphthalenes from four alkynes and one olefin unit via zirconacyclopentadienes and 1,2-Diiodo-3,4,5,6- tetraalkylbenzene
Zhou, Xin,Li, Zhiping,Wang, Hui,Kitamura, Masanori,Kanno, Ken-Ichiro,Nakajima, Kiyohiko,Takahashi, Tamotsu
, p. 4559 - 4562 (2007/10/03)
1,2,3,4-Tetrasubstituted benzene derivatives were prepared by the reaction of zirconacyclopentadienes with vinyl bromide in the presence of NiCl 2(PPh3)2. 1,2-Diiodo-3,4,5,6-tetraalkylbenzenes were formed by treatment of 1,2,3,4-tetraalkylbenzenes with iodine and periodic acid in the presence of a catalytic amount of sulfuric acid. Reaction of the 1,2-diiodo-3,4,5,6-tetraalkylbenzenes with zirconacyclopentadienes in the presence of a stoichiometric amount of CuCl gave sterically crowded octasubstituted naphthalenes in moderate yields.
