415718-71-7Relevant academic research and scientific papers
Palladium-catalyzed hydroxycarbonylation as the key step in the synthesis of a carbon-14 labeled Maxi-K channel blocker
Simeone, Joseph P.,Braun, Matthew P.,Liu, Luping,Natarajan, Swaminathan R.
, p. 511 - 516 (2011/08/09)
Carbon-14 labeled sodium formate was utilized for the preparation of a radiolabeled tracer to support the development of a Maxi-K channel blocker. Key to the process was a palladium-catalyzed hydroxycarbonylation of a bromoarene for installation of the radiolabel. Copyright
Separation of "light fluorous" reagents and catalysts by fluorous solid-phase extraction: Synthesis and study of a family of triarylphosphines bearing linear and branched fluorous tags
Zhang,Luo,Curran
, p. 8866 - 8873 (2007/10/03)
Practical syntheses of new triarylphosphines bearing both linear and branched fluorous tags (Rf) are reported. The phosphines have one, two, or all three aryl rings bearing fluorous tags: (Ph)3-nP(C6H4 (CH2)mRf)n. Fluorous-organic partition coefficients have been measured and the retention properties of both the phosphines and the derived phosphine oxides on fluorous reverse phase silica have been studied. While applications relying on liquid-liquid extractive separations of these phosphines may be limited to those bearing three fluorous chains, the technique of solid phase extraction should be broadly applicable to phosphines, phosphine oxides, and derived metal complexes. A parallel platinum-catalyzed allylation of aldehydes with fluorous allyl stannanes illustrates the usefulness of the new fluorous ligands in small-scale synthesis.
