41577-66-6

Upstream product

• 498-66-8 norborn-2-ene 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 12154-91-5 (phenylacetylene)hexacarbonyldicobalt 
• 116156-85-5 (R)-(+)-2,3-O-isopropylideneglycerol-1-diphenylphosphane 
• 122474-08-2 Co₂(CO)5(HC₂Ph)(PBu₃) 
• 498-66-8 norbornene 
• 81495-75-2 (-)₅₉₈-N,N-bis(diphenylphosphino)-S-α-phenylethylamine 
• 102-92-1 Cinnamoyl chloride 
• 123-73-9 crotonaldehyde 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 15226-74-1 dicobalt octacarbonyl 

Relevant academic research and scientific papers

A stable catalyst of the Pauson-Khand annelation

A practical catalytic-in-cobalt version of the PKA is clearly a desirable objective and there has been much research towards this goal in recent years. Systems developed to date, however, require either the use of high temperatures and high carbon monoxid

Advances in the cobalt-catalysed Pauson-Khand reaction: Development of a sulfide-promoted, microwave-assisted protocol

The development of a sulfide-promoted, microwave-assisted Pauson-Khand reaction has enabled the formation of fused cyclopentenones using sub-stoichiometric quantities of a cobalt mediator over rapid reaction times and with no requirement for an external source of toxic carbon monoxide gas. This protocol displays applicability to both intra- and intermolecular Pauson-Khand reaction examples.

Nitrous Oxide Promoted Pauson-Khand Cycloadditions

A Pauson-Khand cycloaddition of alkynes, alkenes, and carbon monoxide promoted by cobalt carbonyl and nitrous oxide to furnish cyclopentenones is described. Preliminary mechanistic experiments suggest that nitrous oxide functions in a manner similar to th

CoBr2-TMTU-zinc catalysed-Pauson-Khand reaction

A cobalt-TMTU complex, derived from the in situ reduction of CoBr 2 with Zn in the presence of TMTU, can catalyze Pauson-Khand reaction at a balloon pressure of CO, which enables the synthesis of structurally diverse cyclopentenones. This catal

Hydrogen-activated benzylidynetricobalt nonacarbonyl: Carbonylative cyclization of enynes in synthesis gas without reducing substrates and products

Benzylidynetricobalt nonacarbonyl was activated by hydrogen and catalyzed the carbonylative cyclization of enynes without reducing substrates and products. The Japan Institute of Heterocyclic Chemistry.

Cobalt oxide supported gold nanoparticles as a stable and readily-prepared precursor for the in situ generation of cobalt carbonyl like species

A treatment of cobalt oxide supported gold nanoparticles (Au/Co 3O4) under syngas atmosphere effectively generated a cobalt carbonyl-like active species in the reaction vessel. The preparation of Au/Co3O4 was quite simple and the in situ generated cobalt species could be used as a stable and easy handling alternative for dicobalt octacarbonyl without bothersome purification prior to use. The reactions, which are sensitive to the purity of the dicobalt octacarbonyl, such as the alkoxycarbonylation of epoxides and the Pauson-Khand reaction, smoothly progressed with Au/Co3O4.

Chiral and achiral phosphine derivatives of alkylidyne tricobalt carbonyl clusters as catalyst precursors for (asymmetric) inter- and intramolecular Pauson-Khand reactions

Phosphine derivatives of alkylidyne tricobalt carbonyl clusters have been tested as catalysts/catalyst precursors in intermolecular and (asymmetric) intramolecular Pauson-Khand reactions. A number of new phosphine derivatives of the tricobalt alkylidyne clusters [Co3(μ3-CR)(CO) 9] (R = H, CO2Et) were prepared and characterised. The clusters [Co3(μ3-CR)(CO) 9-x(PR′3)x] (PR′3 = achiral or chiral monodentate phosphine, x = 1-3) and [Co3(μ 3-CR)(CO)7(P-P)] (P-P = chiral diphosphine; 1,1′- and 1,2-structural isomers) were assayed as catalysts for intermolecular and (asymmetric) intramolecular Pauson-Khand reactions. The phosphine-substituted tricobalt clusters proved to be viable catalysts/catalyst precursors that gave moderate to very good product yields (up to ～90%), but the enantiomeric excesses were too low for the clusters to be of practical use in the asymmetric reactions. The Royal Society of Chemistry.

An efficient catalytic protocol for the Pauson-Khand reaction

New experimental conditions have been developed for an efficient catalytic Pauson-Khand reaction. These are based on the use of a mixture of molecular sieves and tert-butanol as inducers of the process. This mixture, with the appearance of a paste, is abl

Development of intermolecular additive free Pauson-Khand reactions for estrone E-ring extension using microwaves

Intermolecular additive free microwave (MW) promoted and cobalt octacarbonyl mediated Pauson-Khand reaction (PKR) performance was improved for estrone ring extension. The reaction development with norbornene and cyclopentene produced cyclopentenones in yields of comparable levels with those previously obtained with the aid of chemical additives as promoters. The PKRs with norbornene demonstrated that a low cobalt complex concentration increases yields, especially for the aliphatic alkynes. Furthermore, a boost for the MW PKR could be obtained by a gradual cobalt complex addition. These expedients combined with the use of an excess of free and cobalt complexed alkyne led to successful estrone ring system extension with various alkynes.

Poly(ethylene glycol) stabilized Co nanoparticles as highly active and selective catalysts for the Pauson-Khand reaction

PEG-stabilized cobalt nanoparticles were prepared by thermal decomoposition of [Co2(CO)8] in PEG and were shown to be highly active and selective catalysts, for intra- and intermolecular Pauson-Khand reactions (PKR), in organic solvents or aqueous media. The Royal Society of Chemistry.