415908-03-1Relevant articles and documents
Use of EP4 receptor ligands in the treatment of IL-6 involved diseases
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Page 28, (2010/02/06)
Methods of treating IL-6 involved diseases with EP4 receptor ligands, including EP4 receptor antagonists. Assays to determine the effect of test compounds on PGE2-induced whole blood cells activation.
EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS
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, (2008/06/13)
The invention features a method of treating rheumatoid arthritis in a mammal comprising administering an agent that inhibits prostaglandin EP4 receptor (EP4) activity. Also featured is a method of identifying agents that selectively inhibit EP4 activity in vivo.