41591-35-9

Upstream product

• 35084-69-6 N-t-butyloxycarbonyl-L-alanyl-L-proline benzyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 

Downstream Products

• 97280-49-4 N^α-(isopropoxyphenoxyphosphoryl)-L-alanyl-L-proline benzyl ester 
• 97280-47-2 N^α-<(2-phenylethyl)phenoxyphosphoryl>-L-alanyl-L-proline benzyl ester 
• 249302-44-1 Boc-Asp(O-2-Ada)-Ala-Pro-OBzl 
• 249302-46-3 Boc-Lys(2-Adoc)-Asp(O-2-Ada)-Ala-Pro-OBzl 
• 168764-14-5 Boc-Glu(O-cHex)-Lys(2-Adoc)-Asp(O-2-Ada)-Ala-Pro-OH 
• 249302-47-4 Boc-Glu(O-cHex)-Lys(2-Adoc)-Asp(O-2-Ada)-Ala-Pro-OBzl 
• 97280-41-6 N^α-(phenoxyphosphoryl)-L-alanyl-L-proline dipotassium salt 
• 97280-40-5 N^α-(diphenoxyphosphoryl)-L-alanyl-L-proline dicyclobenzylamine salt 
• 63769-97-1 Boc-Ala-Ala-Pro-O-Bzl 

Relevant academic research and scientific papers

A lanthanide(III) triflate mediated macrolactonization/solid-phase synthesis approach for depsipeptide synthesis

The effect of dysprosium(III) triflate on macrolactonization reactions to form depsipeptides using MNBA (Shiina's reagent) is reported. Improved yields were obtained for the formation of 16-membered depsipeptides using lanthanide triflate additives. The use of a macrocyclization strategy permits the use of a semiautomated solid-phase synthesis approach for the rapid synthesis of analogues of the antibacterial A54556 acyldepsipeptides in only two physical operations, requiring only final product purification after cyclization.

Amino acids and peptides. LIV. Application of 2-adamantyl derivatives as protecting groups to the synthesis of peptide fragments related to Sulfolobus solifataricus ribonuclease. I

The 2-adamantyloxycarbonyl group was employed for the protection of the ε-amino group of Lys and the hydroxyl group of Tyr, and the 2-adamantyl ester was employed for the protection of the β-carboxyl group of Asp in order to construct eight peptide segments as building blocks for the preparation of peptide fragments related to the sequence of Sulfolobus solifataricus Ribonuclease. The usefulness of the above protecting groups developed in our laboratory was confirmed.

Peptidase inhibitors

This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.

N-Carboxyalkylproline-containing tripeptides

Certain N-carboxyalkyl prolyl-containing tripeptides have been prepared and found to improve kidney function. A species of the group of new compounds is N-(2-carboxyethyl)-L-prolyl-L-alanyl-L-proline which has diuretic activity and increases renal blood f