41591-35-9

Basic information

• Product Name: L-Proline, 1-L-alanyl-, phenylmethyl ester, monohydrochloride
• CAS NO: 41591-35-9
• Molecular Formula: C15H20N2O3.ClH
• Molecular Weight: 312.796
• Mol File: 41591-35-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-L-alanyl-, phenylmethyl ester, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-L-alanyl-, phenylmethyl ester, monohydrochloride(41591-35-9)
• EPA Substance Registry System: L-Proline, 1-L-alanyl-, phenylmethyl ester, monohydrochloride(41591-35-9)

Safety Data

• Hazardous Substances Data: 41591-35-9(Hazardous Substances Data)

Upstream product

• 35084-69-6 N-t-butyloxycarbonyl-L-alanyl-L-proline benzyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 

Downstream Products

• 249302-44-1 Boc-Asp(O-2-Ada)-Ala-Pro-OBzl 
• 82009-36-7 N-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-L-proline 
• 97280-40-5 N^α-(diphenoxyphosphoryl)-L-alanyl-L-proline dicyclobenzylamine salt 
• 97280-41-6 N^α-(phenoxyphosphoryl)-L-alanyl-L-proline dipotassium salt 
• 249302-47-4 Boc-Glu(O-cHex)-Lys(2-Adoc)-Asp(O-2-Ada)-Ala-Pro-OBzl 
• 168764-14-5 Boc-Glu(O-cHex)-Lys(2-Adoc)-Asp(O-2-Ada)-Ala-Pro-OH 
• 249302-46-3 Boc-Lys(2-Adoc)-Asp(O-2-Ada)-Ala-Pro-OBzl 

Relevant articles and documents

A lanthanide(III) triflate mediated macrolactonization/solid-phase synthesis approach for depsipeptide synthesis

The effect of dysprosium(III) triflate on macrolactonization reactions to form depsipeptides using MNBA (Shiina's reagent) is reported. Improved yields were obtained for the formation of 16-membered depsipeptides using lanthanide triflate additives. The use of a macrocyclization strategy permits the use of a semiautomated solid-phase synthesis approach for the rapid synthesis of analogues of the antibacterial A54556 acyldepsipeptides in only two physical operations, requiring only final product purification after cyclization.

Peptidase inhibitors

This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.