415920-05-7

Basic information

• Product Name: (1R,2R)-1,2-diphenyl-2-(4-trifluoromethylbenzyloxy)ethyl phenylglyoxylate
• Synonyms: (1R,2R)-1,2-diphenyl-2-(4-trifluoromethylbenzyloxy)ethyl phenylglyoxylate
• CAS NO: 415920-05-7
• Molecular Weight: 504.505
• Mol File: 415920-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2R)-1,2-diphenyl-2-(4-trifluoromethylbenzyloxy)ethyl phenylglyoxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-1,2-diphenyl-2-(4-trifluoromethylbenzyloxy)ethyl phenylglyoxylate(415920-05-7)
• EPA Substance Registry System: (1R,2R)-1,2-diphenyl-2-(4-trifluoromethylbenzyloxy)ethyl phenylglyoxylate(415920-05-7)

Safety Data

• Hazardous Substances Data: 415920-05-7(Hazardous Substances Data)

Upstream product

• 415919-93-6 (4R,5R)-2-(4-trifluoromethylphenyl)-4,5-diphenyl-1,3-dioxolane 
• 52340-78-0 (R,R)-hydroxybenzoin 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 611-73-4 Benzoylformic acid 
• 415919-99-2 (1R,2R)-1,2-diphenyl-2-(4-trifluoromethylbenzyloxy)ethanol 

Relevant articles and documents

Monobenzylethers of (R,R)-1,2-diphenylethane-1,2-diol as a possible alternative to cyclohexyl-based chiral auxiliaries in the stereoselective reduction of α-ketoesters

The monobenzylethers of (R,R)-1,2-diphenylethane-1,2-diol have been used as chiral auxiliaries in the stereoselective reduction of the corresponding phenylglyoxylates. The diastereoselectivity of the reduction with either L-selectride or DIBAL was found to be strictly dependent on the nature of the substitution on the aromatic ring of the auxiliary and a maximum d.r. of 87:13 was obtained with the p-CF3 substituted derivative. This investigation also shows that with open chain chiral auxiliaries diastereoselectivities of preparative interest can be achieved, suggesting that such auxiliaries can constitute a promising alternative to the commonest cyclohexyl-based ones.