415923-82-9Relevant academic research and scientific papers
Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors
Webster, Scott P.,Ward, Peter,Binnie, Margaret,Craigie, Eilidh,McConnell, Kirsty M.M.,Sooy, Karen,Vinter, Andy,Seckl, Jonathan R.,Walker, Brian R.
, p. 2838 - 2843 (2007)
A series of adamantyl amide 11β-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11β-HSD1 over 11β-HSD2 and possess excellent cellular potency in human and murine 11β-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.
