415927-31-0Relevant academic research and scientific papers
PHTHALAZINONE-DERIVATIVES AS PDE4 INHIBITORS
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Page/Page column 30-31, (2008/06/13)
The compounds of a certain formula (1), in which R1, R2, R3, R9 and n have the meanings as given in the description, are novel effective PDE4 inhibitors.
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones
Van der Mey, Margaretha,Boss, Hildegard,Couwenberg, Dennis,Hatzelmann, Armin,Sterk, Geert J.,Goubitz, Kees,Schenk, Henk,Timmerman, Hendrik
, p. 2526 - 2533 (2007/10/03)
Recently, we reported that 4-catechol-substituted cis-(±)-4a,5,6,7,8,8a-hexa- and cis-(±)- 4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones show potent inhibition of phosphodiesterase (PDE4) activity, while the corresponding trans racemic mixtures exhibit only w
