41625-15-4Relevant academic research and scientific papers
Platinum(IV)-Catalyzed Synthesis of Unsymmetrical Polysubstituted Benzenes via Intramolecular Cycloaromatization Reaction
Zheng, Shuyan,Zhang, Jinghua,Shen, Zhengwu
supporting information, p. 2803 - 2808 (2015/09/28)
A one-pot synthesis of polysubstituted benzene derivatives was achieved via a platinum(IV)-catalyzed intramolecular cycloaromatization reaction. The reaction proceeds via a tandem skeletal rearrangment, dehydration and double bond isomerization, which proved to be very useful for the syntheses of a range of interesting polyalkyl-substituted benzenes.
Highly Diastereoselective Synthesis of Substituted Epichlorohydrins and Regioselective Preparation of Allyl Alcohols using Chloro or Idomethyllithium
Concellon, Jose M.,Llavona, Lujan,Bernad, Pablo L. Jr.
, p. 5573 - 5584 (2007/10/02)
Substituted epichlorohydrins 3 or 6 are obtained α-bromo or α-chlorocarbonyl compounds (1 or 4) and chloro or iodomethyllithium, respectively.Starting from α-bromocarbonyl compounds 1 or acyclic α-chloro ketones the reaction takes place with total diastereoselectivity.Treatment of epichlorohydrins 3 or 6 with lithium iodide affords the same substituted allyl alcohols 7 in a regioselective manner.A mechanism to explain this transformation is proposed.Regioisomeric allyl alcohols 11 are prepared by reaction of epichlorohydrins 6 with lithium powder.
