4164-15-2Relevant academic research and scientific papers
β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders
Vaidergorn, Miguel M.,Carneiro, Zumira A.,Lopes, Carla D.,de Albuquerque, Sérgio,Reis, Felipe C.C.,Nikolaou, Sofia,Mello, Juliana F.R. e,Genesi, Giovani L.,Trossini, Gustavo H.G.,Ganesan,Emery, Flavio S.
, p. 657 - 664 (2018/08/23)
It is known that aziridines and nitrogen mustards exert their biological activities, especially in chemotherapy, via DNA alkylation. The studied scaffold, 2-phenyl-1-aziridine, provides a distinct conformation compared to commonly used aziridines, and the
Regioselective ring opening of epoxides by nucleophiles mediated by lithium bistrifluoromethanesulfonimide
Cossy, Janine,Bellosta, Véronique,Hamoir, Claire,Desmurs, Jean-Roger
, p. 7083 - 7086 (2007/10/03)
In the presence of LiNTf2, epoxides undergo ring opening with high regioselectivity and in good yield when they are treated with nucleophiles such as amines, hydrazines and thiophenol.
