4164-20-9Relevant academic research and scientific papers
β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders
Vaidergorn, Miguel M.,Carneiro, Zumira A.,Lopes, Carla D.,de Albuquerque, Sérgio,Reis, Felipe C.C.,Nikolaou, Sofia,Mello, Juliana F.R. e,Genesi, Giovani L.,Trossini, Gustavo H.G.,Ganesan,Emery, Flavio S.
, p. 657 - 664 (2018/08/23)
It is known that aziridines and nitrogen mustards exert their biological activities, especially in chemotherapy, via DNA alkylation. The studied scaffold, 2-phenyl-1-aziridine, provides a distinct conformation compared to commonly used aziridines, and the
Regioselective ring opening of epoxides by nucleophiles mediated by lithium bistrifluoromethanesulfonimide
Cossy, Janine,Bellosta, Véronique,Hamoir, Claire,Desmurs, Jean-Roger
, p. 7083 - 7086 (2007/10/03)
In the presence of LiNTf2, epoxides undergo ring opening with high regioselectivity and in good yield when they are treated with nucleophiles such as amines, hydrazines and thiophenol.
The Reaction of Phenylglyoxal with Primary Aliphatic and Aromatic Amines. Synthesis of Phenylglyoxal Monoimines and some Derivatives.
Alcaide, Benito,Escobar, Gerardo,Perez-Ossorio, Rafael,Plumet, Joaquin,Sanz, Dionisia
, p. 1466 - 1488 (2007/10/02)
Condensation of phenylglyoxal with primary aliphatic amines yields the related keto-aldimines.When primary aromatic amines are used, aldimines, amino-hydroxy-ketones, diamino-ketones, and alkoxy-amino-ketones are obtained depending upon the nature of the amine and the experimental conditions.Alternatively the monoimines can be obtained by dehydration of C-hydroxyphenacylarylamines and by demethanolation of C-methoxyphenacylarylamines both on treatment with Pd/C catalyst.Reduction of phenylglyoxal monoimines with sodium borohydride yielded H-substituted 1-phenyl-2-aminoethanols and 1,3-dipolar cycloaddition of the imines with p-chlorobenzonitrile oxide afforded 4-substituted 5-benzoyl-3-(p-chlorophenyl)-4,5-dihydro-1,2,4-oxadiazoles.
