4165-98-4

Usage

Uses

Used in Pharmaceutical Industry:
B-N-PROPYLGLUTARIC ACID is used as a key intermediate in the synthesis of hypocholesterolemic agents, which are drugs that help lower cholesterol levels in the body. These agents are essential in the treatment and management of conditions such as hypercholesterolemia and atherosclerosis, contributing to improved cardiovascular health.
Additionally, B-N-PROPYLGLUTARIC ACID can be utilized in the development of other pharmaceutical compounds, showcasing its potential as a versatile building block in the pharmaceutical industry. Its unique chemical properties allow for the creation of a wide range of therapeutic agents, further expanding its applications in this field.

InChI:InChI=1/C8H14O4/c1-2-3-6(4-7(9)10)5-8(11)12/h6H,2-5H2,1H3,(H,9,10)(H,11,12)/p-2

Upstream product

• 1515-80-6 sorbic acid methyl ester 
• 18424-76-5 dimethyl malonate sodium salt 
• 141-82-2 malonic acid 
• 123-72-8 butyraldehyde 
• 2612-28-4 2-propyl-propane-1,3-diol 
• 151-50-8 potassium cyanide 
• 20761-65-3 2-propyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester 
• 444102-67-4 3-propyl-1,5-pentanedinitrile 
• 102-71-6 triethanolamine 
• 2163-48-6 diethyl propylmalonate 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 63095-51-2 (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Process for preparing Brivaracetam

A process for the preparation of Brivaracetam, an anti-convulsion drug, is provided comprising Hofmann rearrangement of (S)-3-(2-(chloroamino)-2-oxoethyl) hexanoic acid, followed by cyclization resulting in (R)-4-propyl-pyrrolidin-2-one which on condensation with bromo butyric acid or ester followed by reaction with ammonia results in Brivaracetam.

Pheromones and analogs from Neozeleboria wasps and the orchids that seduce them: a versatile synthesis of 2,5-dialkylated 1,3-cyclohexanediones

Chiloglottone, a wasp pheromone and attractant of sexually deceptive Chiloglottis orchids, and several structural analogs were synthesized. The synthetic approach is facile, high yielding and versatile, enabling rapid divergence to generate dialkylated analogs of chiloglottone. The key transformation was an organocadmium-mediated desymmetrization of glutaric anhydride derivatives. This library of synthetic 2,5-dialkylated 1,3-cyclohexanediones may assist in future identification of natural products in further species.

Tobacco smoke chemistry. 1. A chemical and mass spectrometric study of tobacco smoke alkyl 2-hydroxy-2-cyclopentenones.

A series of alkyl 2-hydroxy-2-cyclopentenones, which comprise biologically and organoleptically active compounds, have been synthesized and subjected to high resolution mass spectrometric studies to clarify structurally significant fragmentation pathways. On the basis of these results, 26 alkyl 2-hydroxy-2-cyclopentenones were identified in the weakly acidic fraction of smoke condensate from American blend type cigarettes, eighteen of which had not been detected in tobacco smoke previously. The utility for identification purposes of the corresponding quinoxaline derivatives, obtained through condensation with o-phenylenediamine, is discussed.