41679-15-6

Usage

Uses

Used in Pharmaceutical Industry:
Dopa is utilized as an active pharmaceutical ingredient for the treatment of Parkinson's disease. It functions as a precursor to dopamine, a neurotransmitter that is often deficient in patients with this condition. By replenishing dopamine levels, dopa can help alleviate symptoms and improve the quality of life for those affected.
Used in Neurodegenerative Disorder Treatment:
Dopa is being investigated for its potential neuroprotective and antioxidant properties, which may contribute to the treatment of other neurodegenerative disorders beyond Parkinson's disease. Its ability to combat oxidative stress and protect neurons could offer new therapeutic avenues for conditions like Alzheimer's and Huntington's disease.
Used in Cosmetics Industry:
In the cosmetics industry, dopa is used in the production of melanin, the pigment responsible for the color of skin, hair, and eyes. Its role in melanogenesis makes it a valuable compound for developing products that address pigmentation concerns and promote even skin tone.
Used in Research and Development:
Dopa's involvement in neurotransmitter synthesis and its potential therapeutic applications make it an important compound for research and development in the fields of neuroscience, pharmacology, and biotechnology. Further study of dopa may lead to the discovery of novel treatments for various neurological and psychiatric conditions.

Upstream product

• 90-01-7 salicylic alcohol 
• 127-17-3 2-oxo-propionic acid 
• 52186-44-4 (S)-N-benzyloxycarbonyl-4-hydroxy-3-hydroxymethylphenylalanine 
• 35149-75-8 L-3-formyltyrosine hydrochloride 
• 698386-62-8 (S)-2-(Benzyloxycarbonyl-hydroxymethyl-amino)-3-(4-hydroxy-3-hydroxymethyl-phenyl)-propionic acid 
• 1164-16-5 Z-L-Tyr-OH 
• 698386-61-7 benzyl (S)-4-(4H-1,3-benzodioxin-6-ylmethyl)-5-oxo-1,3-oxazolane-3-carboxylate 

Relevant academic research and scientific papers

A convenient two step transformation of tyrosine into the antihypertensive amino acid (S)-4-hydroxy-3-hydroxymethylphenylalanine

Treatment of tyrosine with paraformaldehyde and catalytic amounts of p-toluenesulfonic acid, at reflux in toluene, directly generates benzyl (S)-4-(4H-1,3-benzodioxin-6-ylmethyl)-5-oxo-1,3-oxazolane-3-carboxylate, which on treatment with boron trichloride in dichloromethane, affords (S)-4-hydroxy-3-hydroxymethylphenylalanine.

Tyrosine analogues as alternative substrates for protein tyrosine kinase Csk: Insights into substrate selectivity and catalytic mechanism

Protein tyrosine kinases are critical enzymes in cell signal transduction but relatively little is known about the molecular recognition of the tyrosine substrate by these enzymes. Details of tyrosine substrate specificity within the context of a short peptide were investigated for protein tyrosine kinase Csk. It was found that aryl ring functional group substitutions the size of methyl group or smaller were generally well tolerated by the protein tyrosine kinase Csk whereas larger groups caused a decline in substrate efficiency. Extension of the phenol from the peptide backbone by a single methylene was acceptable for phosphorylation whereas removal of a methylene nearly abolished reactivity. Only the L-tyrosine derivative was processed. A negative charge ortho to the phenol hydroxyl was incompatible with substrate reactivity, consistent with previous pH rate profiles which indicated the importance of the neutral phenol. Overall, these studies confirmed the interpretation of a previous linear free energy relationship analysis which suggested that the enzyme followed a dissociative transition state mechanism. Copyright (C) 2000 Elsevier Science Ltd.

L-3-hydroxymethyltyrosine and salts thereof for lowering blood pressure

L-3-Hydroxymethyltyrosine and pharmaceutically acceptable salts thereof useful in lowering blood pressure and compositions thereof.