416848-39-0Relevant academic research and scientific papers
Synthesis of 4,4-difluoro-α-tocopherol using a cross-coupling reaction of bromodifluoroacetate with aryl iodide in the presence of copper powder
Sato, Kazuyuki,Nishimoto, Takashi,Tamoto, Kei,Omote, Masaaki,Ando, Akira,Kumadaki, Itsumaro
, p. 403 - 412 (2002)
Using our new methodology for introduction of a CF2 moiety, 4,4-difluoro-α-tocopherol (2) was synthesized. Thus, 1-iodo-2,5-bis(methoxy-methoxy)-3,4,6-trimethylbenzene (4) was treated with ethyl bromodifluoroacetate (1) in the presence of Cu po
Reactions of ethyl bromodifluoroacetate in the presence of copper powder
Sato,Omote,Ando,Kumadaki
, p. 509 - 515 (2007/10/03)
We have examined the reaction of ethyl bromodifluoroacetate (1) in the presence of copper powder as a procedure for the synthesis of compounds containing a CF2 group. The complex formed in the above reaction reacted with vinyl or aryl iodides t
