416848-41-4

Upstream product

• 34417-76-0 1-iodo-2,5-bis(methoxymethoxy)-3,4,6-trimethylbenzene 
• 4316-69-2 2-iodo-3,5,6-trimethyl-1,4-hydroquinone 
• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 

Downstream Products

• 416848-42-5 4-[2,5-bis(methoxymethoxy)-3,4,6-trimethylphenyl]-4,4-difluoro-2-methylbutanol 
• 416848-44-7 2-[2-{2,5-bis(methoxymethoxy)-3,4,6-trimethylphenyl}-2,2-difluoroethyl]-2-methyloxirane 
• 416848-43-6 4-[2,5-bis(methoxymethoxy)-3,4,6-trimethylphenyl]-4,4-difluoro-2-methyl-1-butene 

Relevant academic research and scientific papers

Synthesis of 4,4-difluoro-α-tocopherol using a cross-coupling reaction of bromodifluoroacetate with aryl iodide in the presence of copper powder

Using our new methodology for introduction of a CF2 moiety, 4,4-difluoro-α-tocopherol (2) was synthesized. Thus, 1-iodo-2,5-bis(methoxy-methoxy)-3,4,6-trimethylbenzene (4) was treated with ethyl bromodifluoroacetate (1) in the presence of Cu po