416860-02-1Relevant articles and documents
Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity
Lafontaine, Jennifer A.,Day, Robert F.,Dibrino, Joe,Hadcock, John R.,Hargrove, Diane M.,Linhares, Michael,Martin, Kelly A.,Maurer, Tristan S.,Nardone, Nancy A.,Tess, David A.,DaSilva-Jardine, Paul
, p. 5245 - 5250 (2007)
A novel series of heterocycle-based analogs were prepared and evaluated for their in vitro and in vivo biological activity as human β3-adrenergic receptor (AR) agonists. Several analogs demonstrated potent agonist activity at the β3-