41693-11-2

Basic information

• Product Name: 2-Hexanone, 1-(triphenylphosphoranylidene)-
• CAS NO: 41693-11-2
• Molecular Formula: C24H25OP
• Molecular Weight: 360.436
• Mol File: 41693-11-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Hexanone, 1-(triphenylphosphoranylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexanone, 1-(triphenylphosphoranylidene)-(41693-11-2)
• EPA Substance Registry System: 2-Hexanone, 1-(triphenylphosphoranylidene)-(41693-11-2)

Safety Data

• Hazardous Substances Data: 41693-11-2(Hazardous Substances Data)

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 73818-55-0 Bestmann ylide 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 638-29-9 n-valeryl chloride 
• 26818-07-5 1-bromo-2-hexanone 
• 603-35-0 triphenylphosphine 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 539-82-2 ethyl n-valerate 

Relevant articles and documents

Carboprost tromethamine related impurity L-amyl 15-ketone and preparation method thereof

The invention relates to a carboprost tromethamine related impurity L-amyl 15-ketone and a preparation method thereof. The preparation method comprises the following steps of: (1) in the presence of afifth organic solvent, carrying out dehydrogenation reaction on methyl triphenyl phosphine halide by using strong base, adding ethyl valerate after reaction for a certain time, continuously reactingfor a certain time to obtain 1-triphenylphosphine 2-hexanone; and (2) carrying out wittig reaction on the 1-triphenylphosphine 2-hexanone obtained in the step (1) and a second organic solvent solutionof benzoyl corey lactone aldehyde to obtain a pentyl-15 ketone crude product. The method has the advantages of simple and convenient operation, high safety, and high yield and purity of an obtained product under optimal conditions, and can meet the requirements for impurity research.

Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy

An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields.

High-pressure accelerated asymmetric organocatalytic friedel-crafts alkylation of indoles with enones: Application to quaternary stereogenic centers construction

An organocatalytic Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones was found to be efficiently accelerated under high-pressure conditions with a low loading of chiral primary amine salts with good yield and enantioselectivity up to 90%. This approach also allows, for the first time, selected indole derivatives containing quaternary stereogenic centers to be obtained from prochiral β,β-disubstituted enones with an enantioselectivity up to 80%.