41702-64-1Relevant articles and documents
Sesquiterpene Cyclizations inside the Hexameric Resorcinarene Capsule: Total Synthesis of δ-Selinene and Mechanistic Studies
Zhang, Qi,Tiefenbacher, Konrad
supporting information, p. 12688 - 12695 (2019/08/12)
The synthesis of terpene natural products remains a challenging task due to the enormous structural diversity in this class of compounds. Synthetic catalysts are unable to reproduce the tail-to-head terpene cyclization of cyclase enzymes, which create this diversity from just a few simple linear terpene substrates. Recently, supramolecular structures have emerged as promising enzyme mimetics. In the present study, the hexameric resorcinarene capsule was utilized as an artificial cyclase to catalyze the cyclization of sesquiterpenes. With the cyclization reaction as the key step, the first total synthesis of the sesquiterpene natural product δ-selinene was achieved. This represents the first total synthesis of a sesquiterpene natural product that is based on the cyclization of a linear terpene precursor inside a supramolecular catalyst. To elucidate the reaction mechanism, detailed kinetic studies and kinetic isotope measurements were performed. Surprisingly, the obtained kinetic data indicated that a rate-limiting encapsulation step is operational in the cyclization of sesquiterpenes.
Sesquiterpene constituents from the essential oil of the liverwort Plagiochila asplenioides
Adio, Adewale Martins,Koenig, Wilfried A.
, p. 599 - 609 (2008/02/03)
The essential oil of the liverwort Plagiochila asplenioides from two different locations in Northern Germany were investigated by chromatographic and spectroscopic methods. Seven compounds were isolated by preparative gas chromatography (GC) and their structures investigated by mass spectrometry (MS), NMR techniques and chemical correlations in combination with enantioselective GC. In addition to known constituents, aromadendra-1(10),3-diene, two aromatic sesquiterpene hydrocarbons, bisabola-1,3,5,7(14)-tetraene and bisabola-1,3,5,7-tetraene, three sesquiterpene ethers, muurolan-4,7-peroxide, plagiochilines W and X, in addition to ent-4-epi-maaliol, could be identified as natural compounds for the first time.
The role of germacrene D as a precursor in sesquiterpene biosynthesis: Investigations of acid catalyzed, photochemically and thermally induced rearrangements
Buelow, Nils,Koenig, Wilfried A
, p. 141 - 168 (2007/10/03)
Germacrene D is considered as a precursor of many sesquiterpene hydrocarbons. We have investigated the acid catalyzed as well as the photochemically and thermally induced rearrangement processes of germacrene D isolated from several Solidago species, which contain both enantiomers of germacrene D. Enantiomeric mixtures of sesquiterpenes of the cadinane, eudesmane (selinane), oppositane, axane, isodaucane, and bourbonane group as well as isogermacrene D were identified as main products and made available as reference compounds for structure investigations and stereochemical assignments of plant constituents. δ-Amorphene, one of the rearrangement products, was identified as a natural product for the first time. The absolute configuration of γ-amorphene was revised by correlation with the absolute configuration of germacrene D. The mechanisms of the rearrangement reactions are discussed. (C) 2000 Elsevier Science Ltd.
STABLE CARBOCATIONS FROM TERPENOIDS. I. GENERATION OF CARBOCATIONS FROM NATURAL SESQUITERPENES - DERIVATIVES OF HEXAHYDRONAPHTHALENE
Osadchii, S. A.,Polovinka, M. P.,Korchagina, D. V.,Pankrushina, N. A.,Dubovenko, Zh. V.,et al.
, p. 1070 - 1081 (2007/10/02)
Stable enantio- and diastereomeric carbocations were generated for the first time from optically active sesquiterpenes (-)-α- and (-)-γ-murolenes (I) and (II) and (+)-γ- and (+)-δ-cadinenes (III) and (IV), and their rearrangements in media with various acidities were studied at tempetatures between -120 and 20 deg C.By the reaction of solutions of salts of the stable cations with nucleophiles the transition was realized from unconjugated dienes (I-IV), isolated from the resin of Pinus silvestris L., to the conjugated dienes (-)-zonarene (V), (-)- and (+)-10-epizonarenes (VI, VII), (-)-trans-isocadinene (VIII), and (-)-bicyclosesquiphellandrene (IX), which had been discovered previously in other plant sources.
