41717-26-4

Basic information

• Product Name: 1-(2 4 6-TRIMETHYLBENZYL)PIPERAZINE
• Synonyms: 1-(2,4,6-Trimethylbenzyl)piperazine; 1-(Mesitylmethyl)piperazine; Piperazine, 1-[(2,4,6-trimethylphenyl)methyl]-
• CAS NO: 41717-26-4
• Molecular Formula: C₁₄H₂₂N₂
• Molecular Weight: 218.34
• Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Piperazines
• Mol File: 41717-26-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 88-98 °C(lit.)
• Boiling Point: 330.2°C at 760 mmHg
• Flash Point: 128.5°C
• Appearance: White to pale yellow/Powder
• Density: 0.989g/cm³
• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 1-(2 4 6-TRIMETHYLBENZYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2 4 6-TRIMETHYLBENZYL)PIPERAZINE(41717-26-4)
• EPA Substance Registry System: 1-(2 4 6-TRIMETHYLBENZYL)PIPERAZINE(41717-26-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 41717-26-4(Hazardous Substances Data)

Usage

General Description

1-(2 4 6-Trimethylbenzyl)piperazine is a chemical compound that belongs to the class of piperazines, which are organic compounds containing a piperazine ring. This particular compound has a piperazine ring substituted with a 2,4,6-trimethylbenzyl (TMB) group. It is often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The TMB group attached to the piperazine ring can impart specific properties to the molecule, making it useful in various applications. Additionally, piperazines are known for their pharmacological activities, so this compound may have potential pharmaceutical uses as well. Overall, 1-(2 4 6-trimethylbenzyl)piperazine is an important intermediate with diverse applications in the synthesis of various organic compounds.

InChI:InChI=1/C14H22N2/c1-11-8-12(2)14(13(3)9-11)10-16-6-4-15-5-7-16/h8-9,15H,4-7,10H2,1-3H3

Upstream product

• 110-85-0 piperazine 
• 1585-16-6 2-chloromethyl-1,3,5-trimethylbenzene 

Downstream Products

• 109006-01-1 3-rifamycin SV 
• 1289155-16-3 (S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2,4,6-trimethylbenzyl)piperazin-1-yl)ethanone 
• 1289155-03-8 2-chloro-1-(4-(2,4,6-trimethylbenzyl)piperazin-1-yl)ethanone 
• 1353278-76-8 3-amino-1-[{4-(2,4,6-trimethylbenzyl)piperazin-1-yl}propanoyl]-6-N-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one 
• 1353278-78-0 C₁₇H₂₅ClN₂O 
• 1218949-63-3 1-[3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl]-2-[4-(2,4,6-trimethylbenzyl)piperazin-1-yl]-ethanone 

Relevant articles and documents

Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein

Respiratory syncytial virus (RSV) is the main cause of lower respiratory tract diseases in infants and young children, with potentially serious and fatal consequences associated with severe infections. Despite extensive research efforts invested in the identification of therapeutic measures, no vaccine is currently available, while treatment options are limited to ribavirin and palivizumab, which both present significant limitations. While clinical and pre-clinical candidates mainly target the viral fusion protein, the nucleocapsid protein or the viral polymerase, our focus has been the identification of new antiviral compounds targeting the viral M2-1 protein, thanks to the presence of a zinc-ejecting group in their chemical structure. Starting from an anti-RSV hit we had previously identified with an in silico structure-based approach, we have designed, synthesised and evaluated a new series of dithiocarbamate analogues, with which we have explored the antiviral activity of this scaffold. The findings presented in this work may provide the basis for the identification of a new antiviral lead to treat RSV infections.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.