41733-55-5

Basic information

• Product Name: sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
• Synonyms: sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate;Fursemide sodium;5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid sodium salt;FuroseMide (sodiuM);Sodium 5-(aminosulfonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
• CAS NO: 41733-55-5
• Molecular Formula: C₁₂H₁₀ClN₂O₅S*Na
• Molecular Weight: 353.73391
• EINECS: 255-526-5
• Mol File: 41733-55-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 582.1°C at 760 mmHg
• Flash Point: 305.9°C
• Appearance: /
• Vapor Pressure: 2.15E-14mmHg at 25°C
• CAS DataBase Reference: sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate(41733-55-5)
• EPA Substance Registry System: sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate(41733-55-5)

Safety Data

• Hazardous Substances Data: 41733-55-5(Hazardous Substances Data)

Usage

General Description

Sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate is a chemical compound with a complex structure containing a combination of elements such as sodium, chlorine, nitrogen, sulfur, and carbon. It is commonly used as an intermediate in the synthesis of organic compounds and pharmaceuticals. This chemical may also have potential applications in the field of agrochemicals and dyes due to its unique structure and properties. Additionally, it is important to handle this chemical with care and according to safety guidelines to avoid any potential hazards associated with its use.

InChI:InChI=1/C12H11ClN2O5S.Na/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19;/h1-5,15H,6H2,(H,16,17)(H2,14,18,19);/q;+1/p-1

Upstream product

• 617-89-0 furan-2-ylmethanamine 
• 2736-23-4 2,4-dichloro-5-sulfamoylbenzoic acid 

Downstream Products

• 159665-36-8 [(N(CH₂(C₇H₄N₂(CH₃)))3)ZnOCOC₆H₂(SO₂NH₂)(NHCH₂C₄H₃O)(Cl)]⁽¹⁺⁾*ClO₄^(1-)*CH₂Cl₂ = C₃₉H₃₇Cl₂N₉O₉SZn*CH₂Cl₂ 
• 54-31-9 4-chloro-2-furfurylamino-5-sulfamoyl-benzoic acid 

Relevant articles and documents

Preparation method of furosemide

The invention provides a preparation method of furosemide and relates to the technical field of pharmaceutical synthesis. The preparation method comprises the following steps: (1) 2,4-dichloro-5-sulfamoylbenzoic acid and alkali are subjected to a reaction in presence of an organic solvent, a reaction liquid is obtained and subjected to aftertreatment, and sodium 2,4-dichloro-5-sulfamoylbenzoic acid is obtained; (2) sodium 2,4-dichloro-5-sulfamoylbenzoic acid and furfurylamine are subjected to a reaction in presence of an organic solvent, furfurylamine and the solvent are recovered through reduced pressure distillation after the reaction, a reaction liquid is obtained and mixed with isopropyl alcohol, a mixture is stirred, crystallized and filtered, and sodium furosemide is obtained; (3) sodium furosemide is subjected to water dissolution, activated carbon decoloration and glacial acetic acid acidification, and a finished furosemide product is obtained. The preparation method has the advantages that raw materials are cheap and available, the cost is low, short time is consumed, reaction steps are short, operation is simple, product quality is good, yield is high, solvents can be recycled and reused, environmental pollution is small and the like, and the preparation method is suitable for industrial production.