41753-55-3

Basic information

• Product Name: Ophiopogonin
• Synonyms: Ophiopogonin;[(25R)-3β-Hydroxyspirost-5-en-1β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-3-O-(β-D-xylopyranosyl)-6-deoxy-β-D-galactopyranoside
• CAS NO: 41753-55-3
• Molecular Formula: C44H70O16
• Molecular Weight: 855.021
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 41753-55-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.42 g/cm³
• CAS DataBase Reference: Ophiopogonin(CAS DataBase Reference)
• NIST Chemistry Reference: Ophiopogonin(41753-55-3)
• EPA Substance Registry System: Ophiopogonin(41753-55-3)

Safety Data

• Hazardous Substances Data: 41753-55-3(Hazardous Substances Data)

Usage

Description

Ophiopogonin is a steroidal saponin extracted from the root of Ophiopogon japonicus, a traditional Chinese medicinal herb. It exhibits a range of pharmacological activities, such as anti-inflammatory, anti-cancer, and immunomodulatory effects. Ophiopogonin is known for its ability to inhibit cancer cell proliferation and induce apoptosis, as well as its capacity to suppress pro-inflammatory cytokines and inflammatory enzyme activity. Moreover, it has the potential to modulate the immune system by promoting the production and activity of specific immune cells, positioning it as a promising therapeutic agent for various health conditions.

Uses

Used in Pharmaceutical Industry:
Ophiopogonin is used as an anti-cancer agent for its ability to inhibit the proliferation of cancer cells and induce apoptosis, making it a potential candidate for cancer treatment.
Ophiopogonin is used as an anti-inflammatory agent due to its capacity to suppress the production of pro-inflammatory cytokines and inhibit the activity of inflammatory enzymes, which can be beneficial in managing inflammatory conditions.
Used in Immunomodulation:
Ophiopogonin is used as an immunomodulatory agent for its ability to modulate the immune system by promoting the production of certain immune cells and enhancing their activity, which can contribute to the body's defense mechanisms against various health challenges.

Upstream product

• 1486510-50-2 25(S)-ruscogenin 1-O-α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-4-O-acetyl-β-D-fucopyranoside 

Downstream Products

• 874485-32-2 25(S)-ruscogenin 

Relevant articles and documents

Three new neuritogenic steroidal saponins from Ophiopogon japonicus (Thunb.) Ker-Gawl

Three new steroidal saponins (1-3) and a known saponin (4) were isolated from Ophiopogon japonicus (Thunb.) Ker-Gawl. Their structures were determined by spectroscopic analyses and chemical derivatization. The isolated compounds (1-4) were potent inducers of neuritogenesis on PC12 cells. Compound 1 showed the highest neuritogenic activity of 46% at 1 μM. The study of structure-activity relationships suggests that aglycone is important for the neuritogenic activity of the compounds. Specific inhibitor experiments and Western blot analysis suggest that 1-induced neuritogenic activity depends on the activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway on PC12 cells.