41759-59-5Relevant academic research and scientific papers
Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4
Guan, Qi,Yang, Fushan,Guo, Dandan,Xu, Jingwen,Jiang, Mingyang,Liu, Chunjiang,Bao, Kai,Wu, Yingliang,Zhang, Weige
, p. 1 - 9 (2014)
A set of novel selenium-containing heterocyclic analogues of combretastatin A-4 (CA-4) have been designed and synthesised using a rigid 1,2,5-selenadiazole as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evalu
Design, synthesis and biological evaluation of 3,4-diaryl-1,2,5-oxadiazole-2/5-oxides as highly potent inhibitors of tubulin polymerization
Hong, Yilang,Zhao, Yinglin,Yang, Lei,Gao, Minghuan,Li, Long,Man, Shuai,Wang, Zhan,Guan, Qi,Bao, Kai,Zuo, Daiying,Wu, Yingliang,Zhang, Weige
, p. 287 - 296 (2019/06/14)
Structure-activity relationships for rigid analogues of combretastatin A-4 (CA-4) were investigated, leading to the discovery of a series of 3,4-diaryl-1,2,5-oxadiazole-N-oxides. Among them, 7n′ and 7n′′ showed remarkable antiproliferative activities agai
