41760-84-3Relevant academic research and scientific papers
Propofol phosphamide derivative, preparation method and medical application thereof
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Paragraph 0089; 0093-0097, (2021/02/24)
The invention discloses a propofol phosphamide derivative, a preparation method and medical application thereof, and relates to a compound represented by a general formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof, and applications in medicine, wherein the structure of the compound represented by the general formula (I) is represented by the following formula, and the groupdefinition is consistent with the definition in the specification.
Synthesis and biochemical evaluation of phosphonoformate oligodeoxyribonucleotides
Yamada, Christina M.,Dellinger, Douglas J.,Caruthers, Marvin H.
, p. 5251 - 5261 (2007/10/03)
Phosphonoformate oligodeoxyribonucleotides were prepared via a solid phase synthesis strategy. The first step in the preparation of appropriate synthons was condensation of bis(N,N-diisopropylamino)-phosphine and diphenylmethylsilylethyl chloroformate in the presence of sodium metal to yield formic acid, [bis(N,N-diisopropylamino)phosphino]-β- (diphenylmethylsilylethyl) ester. The product of this reaction was then condensed with appropriately protected 2′-deoxynucleosides using 4,5-dicyanoimidazole to yield the 3′-O-phosphinoamidite reactive monomers. The exocyclic amines of cytosine, adenine, and guanine were protected with 9-fluorenylmethyloxycarbonyl, and oligodeoxyribonucleotides were synthesized on controlled pore glass using the hydroquinone-O,O′-diacetic acid linker. Synthons were sequentially added to this support using tetrazole as an activator, oxidized to phosphonoformate, and the transient 5′-protecting group was removed with acid. Following total synthesis of an oligomer, protecting groups were removed with TEMED-HF and products purified by HPLC. These analogues were resistant to nucleases, formed duplexes with complementary RNA (A-form), and, as chimeric oligomers containing phosphate at selected sites, stimulated RNase H1 activity.
Phosphonoformic acid esters and pharmaceutical compositions containing same
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, (2008/06/13)
A pharmaceutical preparation containing as active ingredient a compound of the formula STR1 wherein R1 and R2 are the same or different, and each is selected from the group consisting of hydrogen, alkyl groups containing 1-6 carbon atoms; cycloalkyl groups containing 3-6 carbon atoms; cycloalkyl-alkyl groups containing 4-6 carbon atoms; 1-adamantyl; 2-adamantyl, benzyl; and phenyl groups of the formula STR2 wherein R4 and R5 are the same or different and each is selected from the group consisting of hydrogen, halogen, alkyl having 1, 2, or 3 carbon atoms, alkoxy having 1, 2, or 3 carbon atoms, alkoxycarbonyl having 2-7 carbon atoms and alkylcarbonyl groups having 2-7 carbon atoms; or R4 and R5 together form a straight saturated alkylene chain having 3 or 4 carbon atoms and being bound to adjacent positions, i.e. 2,3- or 3,4- in the phenyl ring; and R3 is selected from the group consisting of hydrogen, alkyl groups containing 1-8 carbon atoms; cycloalkyl groups containing 3-8 carbon atoms; cycloalkyl-alkyl groups containing 4-8 carbon atoms; 1-adamantyl; 2-adamantyl; benzyl; and phenyl groups of the formula STR3 wherein R4 and R5 have the meaning given above; provided that at least one of the groups R1, R2 and R3 is alkyl, cycloalkyl, or cycloalkyl-alkyl as defined above, or 1-adamantyl, 2-adamantyl, or benzyl; and provided that when R3 is H, then one of R1 and R2 is alkyl, cycloalkyl, or cycloalkyl-alkyl as defined above, or 1-adamantyl, 2-adamantyl, or benzyl and the other of R1 and R2 is H; or a physiologically acceptable salt or an optical isomer thereof; novel compounds within formula I, methods for their preparation and their medicinal use.
Carbamoylphosphonates
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, (2008/06/13)
This disclosure teaches a method for employing novel carbamoylphosphonates such as ammonium ethyl carbamolyphosphonate, ammonium isopropyl carbamoylphosphonate and ammonium allyl carbamoylphosphonate to regulate the growth rate of plants.
