41763-48-8Relevant academic research and scientific papers
Nickel Catalysed 1,4-Addition of Aryl Groups to Enones Using Aryldialkylaluminium Compounds
Westermann, Juergen,Imbery, Ute,Nguyen, Anh Thu,Nickisch, Klaus
, p. 293 - 298 (2007/10/03)
The transmetallation of arylmagnesium halides or aryllithium with Me2AlCl results in the formation of aryldimethylaluminium compounds.These arylaluminium compounds are useful reagents for conjugate additions to enones in the presence of Ni(acac)2 as a catalyst. 3-Aryl ketones are obtained in good yields in these catalytic reactions.Starting from the 3-oxo-Δ1,4-steroids this method gives access to 1α-arylsteroids. - Keywords: conjugate addition; enones; steroids
