417709-81-0Relevant academic research and scientific papers
Chiral bis(oxazolinyl)phenyl RuII catalysts for highly enantioselective cyclopropanation
Ito, Jun-Ichi,Ujiie, Satoshi,Nishiyama, Hisao
experimental part, p. 4986 - 4990 (2010/08/19)
chemical equation presantation Good to excellent enantioselectivities (up to 99 % ee) of trans-cyclopropane derivatives were achieved in the cyclopropanation of alkenes with tert-buty1 α-diazoacetate by using 0.5 mol % of a mononuclear chiral ruthenium aqua complex containing the chiral bis(oxazolinyl)phenyl ligand, which was obtained via C-H activation by RuCl 3·3H2O in the presence of Mg and cyclooctadiene (cod). Intramolecular cyclopropanation reactions using the new Ru complex also proceed with high yields and excellent enantioselectivities.
