41781-44-6Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF AN AMINE
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Page/Page column 6-7, (2010/11/03)
Process for preparing an amine by reacting an aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group consisting of primary and secondary amines in the presence of a heterogeneous catalyst, wherein the reaction is carried out using a suspended catalyst as heterogeneous catalyst and is carried out in the semibatch mode in which the nitrogen compound as one reactant is placed in the reaction vessel and the aldehyde and/or the ketone as the other reactant is added during the course of the reaction and the aldehyde and/or the ketone is added in portions or continuously to the reaction mixture during the course of the reaction as a function of the achieved conversion of the nitrogen compound until a conversion of the nitrogen compound of at least 95% results, and all or part of the catalyst remains in the reaction vessel after the reaction batch and is reused for the next reaction batch.
A general synthesis of amines and hydrazines by oxidation of amidocuprates and zinc-amidocuprates
Cane,Brancaleoni,Dembech,Ricci,Seconi
, p. 545 - 548 (2007/10/03)
A wide range of amines and hydrazines were synthesized according to an electrophilic amination protocol by oxidative decomposition of readily generated lithium- and zinc-amidocyanocuprates. Optimization of the yields was achieved by the appropriate combination of the organometallic cluster and the nature of the oxidizing agent.
Oxidative intramolecular coupling of amidocuprates as a novel route to amines and hydrazines
Alberti, Angelo,Cane, Francesco,Dembech, Pasquale,Lazzari, Dario,Ricci, Alfredo,Seconi, Giancarlo
, p. 1677 - 1681 (2007/10/03)
Amidocuprates, derived from organocopper reagents and lithium amides upon exposure to oxygen at low temperature, provide new amine derivatives in satisfactory yields. Details of this flexible and simple methodology are given. The reaction mechanism is analyzed in terms of an oxidative intramolecular coupling of aminyl radicals with the ligands on Cu in the intermediate amidocuprate. This reaction is a mild and efficient method for N-alkylation, -vinylation, and -arylation by which a number of amines, not easily accessible by normal routes, can be synthesized. Once applied to lithium hydrazides, it also provides a new and straightforward entry to N-substituted hydrazines.
