41789-74-6Relevant academic research and scientific papers
AZEPINE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS
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Page/Page column 9, (2009/04/25)
Compounds of formula (I), pharmaceutical compositions comprising them, and methods for their use are described.
Compositions comprising 1-substituted azacycloalkenes
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, (2008/06/13)
This invention provides compositions comprising a physiologically-active agent and an azacycloalkene having at least one double bond in the ring and of the general formula STR1 wherein X and Y, each, may represent sulfur, oxygen or two hydrogen atoms, A is a straight or branched chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having 1-4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkylformyl; m is 3-7; q is 2m-2x, wherein x equals the number of double bonds in the lactam ring and may be 1, 2 or 3; and R is --CH3, STR2 wherein R" is H or halogen in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.
