41805-36-1

Basic information

• Product Name: C-(1-PIPERIDIN-1-YL-CYCLOHEXYL)-METHYLAMINE
• Synonyms: (1-PIPERIDIN-1-YLCYCLOHEXYL)METHYLAMINE;IFLAB-BB F3284-8098;C-(1-PIPERIDIN-1-YL-CYCLOHEXYL)-METHYLAMINE;CHEMBRDG-BB 4101265;ASINEX-REAG BAS 11719849;TIMTEC-BB SBB010953;OTAVA-BB BB7020410147;1-(1-piperidin-1-ylcyclohexyl)methanamine(SALTDATA: FREE)
• CAS NO: 41805-36-1
• Molecular Formula: C₁₂H₂₄N₂
• Molecular Weight: 196.33
• Product Categories: pharmacetical
• Mol File: 41805-36-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 253.5°Cat760mmHg
• Flash Point: 103.7°C
• Appearance: /
• Density: 0.977g/cm³
• Vapor Pressure: 0.0182mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.27±0.29(Predicted)
• CAS DataBase Reference: C-(1-PIPERIDIN-1-YL-CYCLOHEXYL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(1-PIPERIDIN-1-YL-CYCLOHEXYL)-METHYLAMINE(41805-36-1)
• EPA Substance Registry System: C-(1-PIPERIDIN-1-YL-CYCLOHEXYL)-METHYLAMINE(41805-36-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 41805-36-1(Hazardous Substances Data)

Usage

General Description

C-(1-piperidin-1-yl-cyclohexyl)-methylamine is a chemical compound that contains a piperidine ring attached to a cyclohexyl group, with a methylamine functional group. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. C-(1-PIPERIDIN-1-YL-CYCLOHEXYL)-METHYLAMINE has potential applications in the development of new drugs and treatments for various medical conditions. It is important to handle and use this chemical with caution, as it may have harmful effects if not used properly.

InChI:InChI=1/C12H24N2/c13-11-12(7-3-1-4-8-12)14-9-5-2-6-10-14/h1-11,13H2

Upstream product

• 3867-15-0 1-piperidinocyclohexylcarbonitrile 
• 108-94-1 cyclohexanone 
• 110-89-4 piperidine 

Downstream Products

• 41805-45-2 1-[1-(3,4,5-trimethoxybenzamidomethyl)cyclohexyl]piperidine hydrochloride 
• 1334308-71-2 C₂₁H₃₂N₂O₂ 
• 41805-39-4 1-[1-(formamidomethyl)cyclohexyl]piperidine 
• 150208-50-7 [2-(3,4-Dichloro-phenyl)-ethyl]-(1-piperidin-1-yl-cyclohexylmethyl)-amine 
• 150208-74-5 N-[2-(3,4-Dichloro-phenyl)-ethyl]-N-(1-piperidin-1-yl-cyclohexylmethyl)-formamide 
• 131815-14-0 2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide 

Relevant articles and documents

Discovery of a novel series of selective HCN1 blockers

The discovery of a series of novel, potent, and selective blockers of the cyclic nucleotide-modulated channel HCN1 is disclosed. Here we report an SAR study around a series of selective blockers of the HCN1 channel. Utilization of a high-throughput VIPR assay led to the identification of a novel series of 2,2-disubstituted indane derivatives, which had moderate selectivity and potency at HCN1. Optimization of this hit led to the identification of the potent, 1,1-disubstituted cyclohexane HCN1 blocker, 2-ethoxy-N-((1-(4- isopropylpiperazin-1-yl)cyclohexyl)methyl)benzamide. The work leading to the discovery of this compound is described herein.

1-(3,4-DICHLOROBENZAMIDOMETHYL)-CYCLOHEXYLDIMETHYLAMINE

Compounds of the general formula I: EQU1 in which R1 - R4 which may be the same or different represent hydrogen atoms, or C1-6 straight or branched chain alkyl, alkenyl or alkynyl group or an alkyl group substituted by a cycloalkyl group, or represents a cycloalkyl, alkoxycarbonyl, aryl, arakyl, acyl (which includes anylsulphonyl) groups in which the alkyl group or the alkyl portion of the aralkyl group may be substituted with one or more hydroxy or esterified hydroxy groups and in which the aryl groups or the aryl portion of the acyl or aralkyl group may be substituted by one or more halogen atoms, alkyl groups, hydroxy groups, alkoxy groups, trifluoromethyl, nitro, amino or dialkylamino groups, and in which R5 - R8 which may be the same or different represent hydrogen atoms or alkyl groups except that not all groups may be hydrogen, or R5 and R6 or R7 and R8 together represent a carbonyl (=O) oxygen and in any of the pairs of groups R1 /R2, R3 /R4, R5 /R6 and R7 /R8 may represent a carbocyclic or heterocyclic ring system optionally substituted by lower alkyl or aryl groups, said ring being saturated or unsaturated. These compounds have utility as oral analgesics.