41814-44-2

Usage

Chemical class

Benzothiazole derivatives

Molecular structure

Complex, containing a triazole and benzothiazole fused ring system

Pharmacological activities

Diverse, including antimicrobial, anticancer, and antioxidant properties

Potential applications

Medicine and agriculture

Biological activities

Antimicrobial, anticancer, and antioxidant

Research and development

Promising candidate for drug discovery and agrochemicals

Unique structure

Contributes to its versatile properties and potential for further study

InChI:InChI=1/C8H5N3OS/c12-7-9-10-8-11(7)5-3-1-2-4-6(5)13-8/h1-4H,(H,9,12)

Upstream product

• 103-71-9 phenyl isocyanate 
• 615-21-4 1,3-benzothiazol-2-ylhydrazine 
• 541-41-3 chloroformic acid ethyl ester 
• 20223-29-4 C₈H₇N₃OS 

Relevant academic research and scientific papers

The Base-Promoted Annulation of 2-Hydrazinyl Pyridine and CO2 toward Triazolones

A base-promoted annulation of 2-hydrazinyl pyridine and atmospheric pressure of CO2 has been developed in the presence of silane as reducing reagent, affording a series of triazolones in moderate to excellent yields. CO2 served as a carbonyl source in this transfomation. Moreover, benzamidrazones also worked well under this procedure. Thus, it represents a green, sustainable and straightforward pathway to access triazolone frameworks. (Figure presented.).

Condensation and Cyclization of 2-Hydrazinobenzimidazole, -benzoxazole, and -benzothiazole

2-Hydrazinobenzoxazole (1), -benzimidazole (2), and -benzothiazole (3) were condensed with ethyl chloroformate and/or diethyl oxalate to produce 1,2,4-triazolo- and 1,2,4-triazino-fused ketones of the title azoles respectively.Condensation of 1 and 2 with aromatic aldehydes and/or acetic anhydride produced, 3-aryl- and 3-methyl-substituted 1,2,4-triazolo-fused azoles respectively.The hydrazines 1 and 2 cyclized with acetylacetone to produce the corresponding 2-(1-pyrazolyl) derivatives. 2-Acetylthiazolobenzimidazole reacted with hydroxylamine and/or alkylamines, to produce the corresponding condensation products.Also, it condensed with aromatic aldehydes to give the chalcones.When reacted with benzenediazonium salt, it gave the corresponding 2-arylazo-substituted compounds.

Agent for the control of plant-pathogenic organisms

Methods employing and compositions comprising, for the control of plant-pathogenic organisms, specified triazolobenzoxazole and triazolobenzothiazole compounds; and novel methods for the preparation of the compounds.