41855-64-5Relevant academic research and scientific papers
Fluorodynamers Displaying Tunable Fluorescence on Constitutional Exchanges in Solution and at Solid Film–Solution Interface
Si, Mingran,Zhu, Weijia,Zhang, Yan,Barboiu, Mihail,Chen, Jinghua
supporting information, p. 10191 - 10194 (2020/07/13)
Dynamic covalent polymers—dynamers—are adaptive materials that offer timely variant adaptive macroscopic organization across extended scales. In the current study, imine exchange reactions and fluorescence transfer can occur at the interfaces between vari
Diverse C-6 substituted 4-methyl-2-(2-, 3- and 4-pyridinyl)quinolines: synthesis, in vitro anticancer evaluation and in silico studies
Kouznetsov, Vladimir V.,Robles-Castellanos, Mayra L.,Sojo, Felipe,Rojas-Ruiz, Fernando A.,Arvelo, Francisco
, p. 551 - 561 (2017/02/15)
A series of twelve 4-methyl-2-(2-, 3- and 4-pyridinyl)quinolines 7–9 was synthesized using modified Kametani reaction protocol and their in vitro cytotoxicity was tested against human cancer cell lines MCF-7, SKBR-3, PC3, HeLa, comparing with human dermis
Development of novel vitamin D receptor-coactivator inhibitors
Sidhu, Preetpal S.,Nassif, Nicholas,McCallum, Megan M.,Teske, Kelly,Feleke, Belaynesh,Yuan, Nina Y.,Nandhikonda, Premchendar,Cook, James M.,Singh, Rakesh K.,Bikle, Daniel D.,Arnold, Leggy A.
supporting information, p. 199 - 204 (2014/03/21)
Nuclear receptor coregulators are master regulators of transcription and selectively interact with the vitamin D receptor (VDR) to modulate cell differentiation, cell proliferation, and calcium homeostasis. Herein, we report the syntheses and evaluation of highly potent and selective VDR-coactivator inhibitors based on a recently identified 3-indolylmethanamine scaffold. The most active compound, PS121912, selectively inhibited VDR-mediated transcription among eight other nuclear receptors tested. PS121912 is also selectively disrupting the binding between VDR and the third nuclear receptor interaction domain of the coactivator SRC2. Genetic studies revealed that PS121912 behaves like a VDR antagonist by repressing 1,25-(OH)2D3 activated gene transcription. In addition, PS121912 induced apoptosis in HL-60.
Aqueous extract of the pericarp of Sapindus trifoliatus fruits: A novel 'green' catalyst for the aldimine synthesis
Pore, Santosh,Rashinkar, Gajanan,Mote, Kavita,Salunkhe, Rajeshri
experimental part, p. 1796 - 1800 (2011/08/05)
The catalytic efficiency in organic synthesis of the aqueous extract of the pericarp of Sapindus trifoliatus fruits was evaluated. The synthesis of a series of aldimines from aromatic aldehydes and amines was successfully catalyzed by the extract, whereas aromatic ketones and amines did not yield ketimines under comparable reaction conditions, indicating the chemoselective catalysis of the extract. The catalytic activity of the extract is due to saponins, which have a common structural skeleton containing a pentacyclic triterpenoid part substituted with different carbohydrate side chains. The mild conditions, high yields, and short reaction times not only make this protocol a valuable alternative to the conventional methods, but it also becomes significant under the roof of environmentally greener and safer processes.
