41862-13-9Relevant academic research and scientific papers
Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti-Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation
Zaminelli, Tiago,Magli, Elisa,Frecentese, Francesco,Lescano, Caroline H.,Campos, Rafael,Saccone, Irene,Corvino, Angela,Di Vaio, Paola,Giordano, Flavia,Luciano, Paolo,Fiorino, Ferdinando,Perissutti, Elisa,Santagada, Vincenzo,Severino, Beatrice,Caliendo, Giuseppe,De Nucci, Gilberto
, p. 464 - 475 (2019/05/07)
The increased levels of cyclic nucleotides (cGMP and cAMP) in enterocytes trigger intracellular mechanisms of ion and fluid secretion into the lumen, causing secretory diarrhea. Twelve novel pyridopyrimidines derived from 5-(3,5-bistrifluoromethylphenyl)-
NEW PYRIDOPYRIMIDINES DERIVATIVES COMPOUNDS
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Paragraph 0079-0082, (2016/04/09)
The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
