4187-48-8

Basic information

• Product Name: N-[(E)-(4-chlorophenyl)methylidene]-1-phenylethanamine
• CAS NO: 4187-48-8
• Molecular Formula: C₁₅H₁₄ClN
• Molecular Weight: 243.7314
• Mol File: 4187-48-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 341.3°C at 760 mmHg
• Flash Point: 160.2°C
• Density: 1.05g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: N-[(E)-(4-chlorophenyl)methylidene]-1-phenylethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(E)-(4-chlorophenyl)methylidene]-1-phenylethanamine(4187-48-8)
• EPA Substance Registry System: N-[(E)-(4-chlorophenyl)methylidene]-1-phenylethanamine(4187-48-8)

Safety Data

• Hazardous Substances Data: 4187-48-8(Hazardous Substances Data)

Usage

General Description

N-[(E)-(4-chlorophenyl)methylidene]-1-phenylethanamine, also known as Ephedrine, is a chemical compound with stimulant and decongestant properties. It is commonly used in over-the-counter medications for the treatment of asthma, nasal congestion, and bronchitis. Ephedrine works by activating the sympathetic nervous system, leading to increased heart rate, blood pressure, and bronchodilation. It also has appetite suppressant and thermogenic effects, making it a popular ingredient in weight-loss supplements. However, it can also have potentially dangerous side effects, including increased risk of heart attack and stroke, and is regulated in many countries due to its potential for abuse and misuse.

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 135738-62-4 [(4-Chloro-phenyl)-((S)-1-phenyl-ethylamino)-methyl]-phosphonic acid diethyl ester 

Relevant articles and documents

An investigation towards the diastereoselective synthesis of 3-acetoxy/methoxy/phthalimido-β-lactams using chiral imines

The efficient diastereoselective synthesis of 3-acetoxy/methoxy/phthalimido-β-lactams 2/2′, 3/3′ and 4/4′ respectively was performed using chiral imines 1 obtained from chiral amines. Factors (solvent, temperature, substituent, steric bulk) influencing th

Heterogeneous chiral copper complexes of amino alcohol for asymmetric nitroaldol reaction

Figure presented. Chiral amino alcohols supported on mesoporous silicas were synthesized and evaluated as a new class of chiral ligands in copper-catalyzed nitroaldol reaction under heterogeneous and mild reaction conditions. The activity and enantioselec

[3+2]-cycloaddition reaction between chiral oxaziridines and nitriles: Enantioselective synthesis of 2,3-dihydro-1,2,4-oxadiazoles

Enantiomerically pure 2,3-dihydro-1,2,4-oxadiazoles were synthesized by a cycloaddition reaction between chiral oxaziridines and nitriles. Assignment of absolute configurations was made by X-ray diffraction analysis, NOESY spectra, and theoretical calculations. Georg Thieme Verlag Stuttgart - New York.