4187-48-8

Usage

Uses

Used in Pharmaceutical Industry:
N-[(E)-(4-chlorophenyl)methylidene]-1-phenylethanamine is used as a medication for the treatment of asthma, nasal congestion, and bronchitis. Its stimulant and decongestant properties help alleviate respiratory symptoms by promoting bronchodilation and reducing inflammation.
Used in Weight-Loss Supplements:
Due to its appetite suppressant and thermogenic effects, N-[(E)-(4-chlorophenyl)methylidene]-1-phenylethanamine is used as an ingredient in weight-loss supplements. It helps to increase metabolism and reduce appetite, contributing to weight management efforts.
However, it is important to note that Ephedrine can have potentially dangerous side effects, such as an increased risk of heart attack and stroke. As a result, its use is regulated in many countries due to the potential for abuse and misuse.

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 135738-62-4 [(4-Chloro-phenyl)-((S)-1-phenyl-ethylamino)-methyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

An investigation towards the diastereoselective synthesis of 3-acetoxy/methoxy/phthalimido-β-lactams using chiral imines

The efficient diastereoselective synthesis of 3-acetoxy/methoxy/phthalimido-β-lactams 2/2′, 3/3′ and 4/4′ respectively was performed using chiral imines 1 obtained from chiral amines. Factors (solvent, temperature, substituent, steric bulk) influencing th

Asymmetric induction in the addition of enantiomerically pure H-phosphinate to chiral aldimines: diastereoselective generation of α-amino phosphinates with P,C-stereogenic centers

α-Amino phosphinates with P,C-stereogenic centers were prepared from a P-retained addition of (RP)-(?)-menthyl H-phenylphosphinate to (R)-aldimines with up to 86:14 dr under catalyst and solvent free condition at ambient temperature; the single

Heterogeneous chiral copper complexes of amino alcohol for asymmetric nitroaldol reaction

Figure presented. Chiral amino alcohols supported on mesoporous silicas were synthesized and evaluated as a new class of chiral ligands in copper-catalyzed nitroaldol reaction under heterogeneous and mild reaction conditions. The activity and enantioselec

Generation of azomethine imine and metal-free formal 1,3-dipolar cycloaddition of imine with PhIO: Reaction, scope, and synthesis

Generation of azomethine imine and its scope in regioselective 1,3-dipolar cycloaddition (DC) of imine with PhIO toward highly substituted Δ2-1,2,4-triazoline, 1,2,4-triazole, and their fused, chiral, and sugar-based analogues are demonstrated. The Royal Society of Chemistry.

[3+2]-cycloaddition reaction between chiral oxaziridines and nitriles: Enantioselective synthesis of 2,3-dihydro-1,2,4-oxadiazoles

Enantiomerically pure 2,3-dihydro-1,2,4-oxadiazoles were synthesized by a cycloaddition reaction between chiral oxaziridines and nitriles. Assignment of absolute configurations was made by X-ray diffraction analysis, NOESY spectra, and theoretical calculations. Georg Thieme Verlag Stuttgart - New York.

Chiral oxaziridines in the enantioselective synthesis of isoxazolidines

The stereoselective synthesis of oxaziridines with three stereogenic centres is presented in this paper. The chirality is provided by asymmetric induction, and a possible mechanism for the induced stereoselectivity is also discussed. These small heterocyc

Highly enantioselective syntheses of chiral β-amino alcohols in the presence of chiral TiIV Schiff base complexes as catalysts

Two new chiral Schiff bases 1 and 2 were prepared by condensation of 3,3′-di-tert-butyl-5,5′-methylenebis(salicylaldehyde) and 3,3′-dimethyl-5,5′-methylenebis(salicylaldehyde) with (1R,2S)-(-)-2-aminodiphenylethanol and were characterized by elemental ana