418770-86-2Relevant articles and documents
Asymmetric reduction of halo-substituted arylalkanones with Rhizopus arrhizus
Salvi, Neeta A.,Chattopadhyay, Subrata
, p. 1992 - 1997 (2008/12/22)
The Rhizopus arrhizus-mediated asymmetric reduction of various haloaryl alkanones furnished the respective (S)-carbinols with good to excellent enantioselectivities. It was found that the reaction course was primarily governed by the relative position of the halogen with respect to the carbonyl group, and its size. The relative order of efficacies of the nature of the halogen and their substitution pattern were Br > Cl > F and o- > p- > m-. The ortho-effect was the most predominant factor in the stereochemical outcome of the reaction, which was also confirmed with some non-halo-substituted acetophenones.
