418798-98-8Relevant academic research and scientific papers
Synthesis and Comparative Inotropic Effects of Several Isoquinoline Alkaloids
Khushmatov, Sh. S.,Saidov, A. Sh.,Vinogradova, V. I.,Zhumaev, I. Z.,Zhurakulov, Sh. N.
, (2020)
Compounds 3a [1-(3′,4′-methylenedioxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline] and 3b [1-(6′-bromo-3′,4′-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline] demonstrated dose-dependent (5-75 μM) negative inotropic effects. Compound 5 [1,3-bis-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin- 1-yl)propane] demonstrated a two-phase inotropic effect. The experimental results and a literature analysis suggested that the negative inotropic effects of the tested compounds (3a, 3b, 5) could be due to their influences on the [Ca2+]i concentration through blocking of cardiomyocyte Na+- and Ca2+-channels. The positive inotropic effect of free base 5 could be related to modulation of cardiomyocyte muscarinic receptor activity.
Synthesis of Hydroxyethyl Derivatives of 1-Aryltetrahydroisoquinoline Alkaloids
Zhurakulov,Levkovich,Vinogradova
, p. 1095 - 1098 (2014/03/21)
New hydroxyethyl derivatives of 1-aryltetrahydroisoquinoline alkaloids and diisoquinoline were prepared using a Pictet-Spengler reaction.
Synthesis of 1-aryltetrahydroisoquinoline alkaloids and their analogs
Zhurakulov,Vinogradova,Levkovich
, p. 70 - 74 (2013/06/27)
Three alkaloids of the cryptostylin series and 20 monomolecular and 3 bimolecular 1-aryltetrahydroisoquinoline derivatives were prepared using the Picte-Spengler reaction.
