418808-76-1

Upstream product

• 106501-78-4 tert-butyl (4,4-dimethoxycyclohexa-2,5-dien-1-ylidene)carbamate 

Downstream Products

• 418808-80-7 [(S)R]-4-amino-4-[(p-tolylsulfinyl)methyl]-2,5-cyclohexadienone 

Relevant academic research and scientific papers

Stereoselective synthesis of heterocyclic cage compounds by domino conjugate additions

Heterocyclic cage compounds have been stereoselectively synthesized from enantiopure [(S)R]-[(p-tolylsulfinyl)methyl]-p-quinols or their amine analogues and 2-(trimethylsilyloxy)furan in the presence of Bu4NF. The method is particularly valuable not only because of the stereochemical control but also because the reactions occur in an experimentally simple one-pot procedure through a domino sequence of three consecutive conjugate additions. The intermediate 1,4-adducts could be isolated when the reaction was carried out in the presence of BF3·OEt2.