41886-24-2

Usage

Uses

Used in Pharmaceutical Industry:
2H-1,2,3-Triazole-4-carboxaldehyde, 2-(4-chlorophenyl)is used as a key intermediate for the synthesis of various biologically active compounds, particularly in the development of pharmaceuticals. Its unique structure and reactivity make it a valuable tool for the preparation of diverse molecules with potential therapeutic applications.
Used in Agrochemical Industry:
2H-1,2,3-Triazole-4-carboxaldehyde, 2-(4-chlorophenyl)is also used as a key intermediate in the development of agrochemicals. Its versatility and reactivity enable the synthesis of various compounds with potential applications in crop protection and pest control.
Used in Drug Discovery:
2H-1,2,3-Triazole-4-carboxaldehyde, 2-(4-chlorophenyl)is used as a building block for the synthesis of diverse molecules with potential applications in drug discovery. Its unique structure and reactivity make it a valuable tool for the preparation of compounds that can be further optimized for specific therapeutic targets.
Used in Materials Science:
2H-1,2,3-Triazole-4-carboxaldehyde, 2-(4-chlorophenyl)is used in materials science for the preparation of diverse molecules with potential applications in various fields, such as the development of new materials with unique properties or the improvement of existing materials.

Upstream product

• 17359-08-9 D-Glucose-(4-chlor-phenylosazon) 
• 1073-69-4 N-4-chlorophenylhydrazine 

Downstream Products

• 150981-43-4 (E)-1-(4-Chloro-phenyl)-3-[2-(4-chloro-phenyl)-2H-[1,2,3]triazol-4-yl]-propenone 
• 150981-44-5 (E)-1-(4-Bromo-phenyl)-3-[2-(4-chloro-phenyl)-2H-[1,2,3]triazol-4-yl]-propenone 
• 150981-42-3 (E)-3-[2-(4-Chloro-phenyl)-2H-[1,2,3]triazol-4-yl]-1-phenyl-propenone 
• 177494-48-3 (Z)-4-[2-(4-Chloro-phenyl)-2H-[1,2,3]triazol-4-yl]-3-methyl-but-3-en-2-one 
• 177494-49-4 (Z)-4-[2-(4-Chloro-phenyl)-2H-[1,2,3]triazol-4-yl]-3-phenyl-but-3-en-2-one 
• 177494-94-9 (Z)-6-[2-(4-Chloro-phenyl)-2H-[1,2,3]triazol-4-yl]-5-methyl-2,4-dioxo-hex-5-enoic acid ethyl ester 
• 177494-95-0 (Z)-6-[2-(4-Chloro-phenyl)-2H-[1,2,3]triazol-4-yl]-2,4-dioxo-5-phenyl-hex-5-enoic acid ethyl ester 

Relevant academic research and scientific papers

1-Phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, synthesis and inhibitory effect on alpha-glycosidases

Due to aging and increasingly overweight in human population, the incidence of non-insulin dependent diabetes mellitus (NIDDM or Type 2 DM) is increasing considerably. Therefore, searching for new α-glycosidase inhibitors (GIs) capable of slowing down carbohydrate assimilation by humans is an important strategy towards control of NIDDM. In this report, we disclose the search for new easily accessible synthetic triazoles as anti-diabetic compounds. Two series of non-glycosid triazoles were synthesized (series A and B) and screened against baker's yeast α-glucosidase (MAL12) and porcine pancreatic α-amylase activity (PPA). Of the 60 compounds tested at 500 μM, were considered hits (≥60% inhibition) six triazoles against MAL12 and three against PPA, with the inhibition reaching up to 99.4% on MAL12 and 88.6% on PPA. The IC50 values were calculated for both enzymes and ranged from 54 to 482 μM for MAL12 and 145 to 282 μM for PPA. These results demonstrated the potential activity of simple and non-glycosidic triazoles as an important novel class of GIs for the development of drugs to treat Type 2 DM.