41908-14-9Relevant academic research and scientific papers
New reactivity patterns of copper(I) and other transition metal NHC complexes: application to ATRC and related reactions
Bull, James A.,Hutchings, Michael G.,Luján, Cristina,Quayle, Peter
, p. 1352 - 1356 (2008/09/18)
Pre-formed transition metal-NHC complex is shown to be an effective catalyst for Atom Transfer Radical Cyclisation (ATRC) reactions.
An unusual decarboxylative benzannulation and biaryl formation during copper(I)-promoted halogen atom transfer radical cyclization of 2-allylaryl trichloroacetates
Ram, Ram N.,Tittal, Ram K.,Upreti, Shailesh
, p. 7994 - 7997 (2008/03/14)
CuCl/bpy-promoted halogen atom transfer radical cyclization of 2-allylaryl trichloroacetates in refluxing benzene gave benzannulated chloroarenes and benzannulated symmetrical biaryls along with reductive dehalogenation products. The unusual decarboxylative benzannulation and biaryl formation might be explained by a further intramolecular radical addition on the benzene ring of the eight-membered lactone intermediate, initially formed through 8-endo-trig halogen atom transfer radical cyclization, followed by decarboxylation, radical dimerization and dehydrochlorination reactions.
PROCESS FOR SYNTHESIS OF AROMATIC COMPOUNDS
-
Page/Page column 12; 14, (2008/06/13)
The present invention refers to a process for preparing a compound of the formula (I) wherein R denotes an organic radical which, together with the two carbon atoms to which it is bonded, forms a carbocyclic or heterocyclic ring; R1, R2, R3 and X, independently, denote hydrogen, halogen, nitro, cyano or an organic radical; or R1 and R2 or R2 and R3, together with the carbon atoms to which they are bonded, form a ring; which comprises exposing a compound of the formula (II) wherein R1, R2, R3 and X are defined as given above and Y and Z, independently, have one of the meanings of X; to an energy source in the presence of a catalyst system.
A remarkably simple and efficient benzannulation reaction
Bull, James A.,Hutchings, Michael G.,Quayle, Peter
, p. 1869 - 1872 (2008/03/12)
(Chemical Equation Presented) On a short fuse: Although fused aromatic rings are common structural motifs in natural products, there are relatively few direct methods for the preparation of such systems from acyclic precursors. An atom-transfer radical cyclization carried out under microwave (MW) irradiation has now been developed which gives rapid access to functionalized aromatic compounds from readily available starting materials (see scheme).
