41918-06-3

Upstream product

• 98960-69-1 5-methyl-2-methylsulfanyl-benzylamine 
• 64025-11-2 (2-chloromethyl-4-methyl-phenyl)-methyl sulfide 
• 114887-40-0 2-aminomethyl-4-methyl-thiophenol 

Relevant academic research and scientific papers

Processes for producing isothiazole derivatives

A method for producing a 1,2-benzisothiazole characterized by treating a 2-(alkylthio)benzaldehyde oxime with a halogen compound; a method for producing a 3-halo-1,2-benzisothiazole characterized by treating a 1,2-benzisothiazole with a halogenating agent; and a method for producing a 1-(1,2-benzisothiazol-3-yl)piperazine characterized by reacting the obtained 3-halo-1,2-benzisothiazoles with a piperazine. By the method of the present invention, 1,2-benzisothiazoles and 3-halo-1,2-benzisothiazoles, which are useful as intermediates for pharmaceutical compositions such as psychotropic agents, and 1-(1,2-benzisothiazole-3-yl)piperazines synthesized therefrom can be obtained in a high yield without using expensive starting materials by shorter and simpler process than conventional methods.